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Figure 7 | Breast Cancer Research

Figure 7

From: Inhibition of phosphatidylcholine-specific phospholipase C results in loss of mesenchymal traits in metastatic breast cancer cells

Figure 7

Schematic representation of major links between pathways of biosynthesis and catabolism of phosphatidylcholine (PtdCho) and sphingomyelin (SM) and their relationships with membrane synthesis and apoptosis. The dose-dependent effects of D609 on phospholipase C (PLC) and sphingomyelin synthase (SMS) inhibition and on stimulation of ceramide synthase are described in the Discussion section. CCT, phosphocholine-cytidylyl transferase; CDP-Cho, cytidine 5'-diphosphocholine; Cho, free choline; ChoK, choline kinase; DAG, diacylglycerol; PCho, phosphocholine; SMase, sphingomyelinase.

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Breast Cancer Research

ISSN: 1465-542X

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