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Table 1 Functional Annotation Clustering of Genes Independently Regulated by Runx2 and E2 in MCF7/Rx2dox Cells

From: Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2

Category

Term

P value

Annotation Cluster 1

Enrichment Score: 4.50

 

GOTERM_BP_FAT

GO:0001944~vasculature development

2.22E-05

GOTERM_BP_FAT

GO:0048514~blood vessel morphogenesis

2.72E-05

GOTERM_BP_FAT

GO:0001568~blood vessel development

5.40E-05

Annotation Cluster 2

Enrichment Score: 4.48

 

GOTERM_BP_FAT

GO:0016477~cell migration

2.55E-05

GOTERM_BP_FAT

GO:0048870~cell motility

3.77E-05

GOTERM_BP_FAT

GO:0051674~localization of cell

3.77E-05

  1. DAVID Functional Clustering brings the similar, redundant, and heterogeneous annotation contents from the same or different resources into annotation groups. Enrichment Score ranks the significance of biological functions and measured as geometric mean of member's P-values in a corresponding annotation cluster. Shown are the top two annotation clusters for the 530 'common' genes, those independently regulated by Runx2 and E2.