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Table 2 Reversal effects of nomegestrol and other reversal agents on drug resistance in MCF7/WT and MCF7/ADR cells (MTT assay)

From: Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line

  

MCF7/WT

MSF7/ADR

Drug

Concentration (μM)

IC50

Reversal (fold)

IC50

Reversal (fold)

ADM

 

0.40 ± 0.12

 

30.0 ± 6.24

 

NOM

20

0.38 ± 0.09

1

1.4 ± 0.32***

21

 

10

0.40 ± 0.08

1

2.5 ± 0.45**†

12

 

5

0.41 ± 0.07

1

3.8 ± 0.63*†

8

MG

20

0.41 ± 0.09

1

3.0 ± 0.84**‡

10

 

10

0.39 ± 0.11

1

4.3 ± 1.01*‡

7

 

5

0.39 ± 0.12

1

10.0 ± 1.42*‡

3

TAM

20

0.36 ± 0.07

0.9

1.7 ± 0.37**

18

 

10

0.38 ± 0.05

1

3.0 ± 0.64**

10

 

5

0.41 ± 0.06

1

6.0 ± 1.14*

5

DRO

20

0.40 ± 0.12

1

2.7 ± 0.81**‡

11

 

10

0.42 ± 0.14

1

5.0 ± 0.87*‡

6

 

5

0.39 ± 0.08

1

10.0 ± 2.04*‡

3

VRP

20

0.36 ± 0.10

0.9

1.4 ± 0.43***

22

 

10

0.38 ± 0.07

1

2.1 ± 0.61**

14

 

5

0.39 ± 0.06

1

4.3 ± 0.91*

7

  1. Results are means ± standard deviation. Statistical significance compared with control: ***, P < 0.005; **, P < 0.01; *, P <0.05; compared with 20 μM NOM: † P <0.05; compared with responsive concentration of NOM, ‡ P <0.05. ADM, adriamycin; DRO, droloxifene; MDR, multidrug resistance; MG, megestrol; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide; NOM, nomegestrol; TAM, tamoxifen; VRP, verapamil.
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Breast Cancer Research

ISSN: 1465-542X

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