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Epigenetics of breast cancer
Breast Cancer Research volume 13, Article number: O6 (2011)
DNA methylation and histone modifications have important roles in normal mammary differentiation and the development of breast cancer. Epigenetically mediated silencing of tumor suppressor coding genes and microRNAs is a hallmark of human breast tumors. CpG island hypermethylation is starting to be used as a biomarker of the disease, such as BRCA1 hypermethylation as a predictor of response to PARP inhibitors. Most importantly, both DNA methylation and histone modifications are new targets for upcoming drugs.
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Esteller, M. Epigenetics of breast cancer. Breast Cancer Res 13 (Suppl 2), O6 (2011). https://0-doi-org.brum.beds.ac.uk/10.1186/bcr3004
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DOI: https://0-doi-org.brum.beds.ac.uk/10.1186/bcr3004