Figure 1

Expression profiling and target prediction of microRNA (miRNA) and genes in histologically normal (HN) and ductal carcinoma in situ (DCIS). (A) and (B) Hierarchical clustering heatmaps of (A) miRNA (P < 0.005, fold change >3) and (B) mRNA (P < 0.05, fold change >1.5) overexpressed (red) and underexpressed (green) in DCIS versus paired HN. Brackets indicate the most significant miRNA and probe sets. Rows, transcripts/miRNA; columns, profiled patient samples; shaded boxes, lesion type. (C) Venn diagram depicting number of predicted functional pairs for each miRNA target prediction algorithm (PicTar, TargetScan and miRANDA) and the intersection of algorithms, first and second queries are separated by a forward slash.