Rare, evolutionarily unlikely missense substitutions in CHEK2contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study

Table 2 Distribution of patients and controls by age, race or ethnicity, and study center^a

Distributions	Patients, n(%)	Controls, n(%)
Age range, yr
≤30	106 (8.1%)	66 (6.0%)
31-35	322 (24.7%)	171 (15.4%)
36-40	434 (33.3%)	231 (20.8%)
41-45	441 (33.8%)	199 (17.9%)
46-50	0 (0.0%)	230 (20.7%)
51-55	0 (0.0%)	212 (19.1%)
Total	1,303 (100.0%)	1,109 (100.0%)
Race or ethnicity
Caucasian	843 (64.7%)	956 (86.2%)
East Asian	204 (15.7%)	70 (6.3%)
Latina	158 (12.1%)	47 (4.2%)
Recent African ancestry	98 (7.5%)	36 (3.2%)
Total	1,303 (100.0%)	1,109 (100.0%)
Study center
Breast CFR Australia	588 (45.1%)	513 (46.3%)
Breast CFR Canada	302 (23.2%)	461 (41.6%)
Breast CFR Northern California	413 (31.7%)	135 (12.2%)
Total	1,303 (100.0%)	1,109 (100.0%)

^a Patients and controls excluded because of poor mutation-screening performance are not included; percentage data are the percentages of the total number of patient or control DNA in the category indicated that met the mutation-screening quality control criterion; Breast CFR, Breast Cancer Family Registry.

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