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Table 3 WST-1 proliferation assay for BT474 cells treated with trastuzumab and tamoxifen

From: Anti-tumor effects of retinoids combined with trastuzumab or tamoxifen in breast cancer cells: induction of apoptosis by retinoid/trastuzumab combinations

 

Fraction affected

 

Dose

Trastuzumab

Tamoxifen

Tzmab + Tam

Combination index

0.2

0.27 ± 0.006

0.20 ± 0.028

0.39 ± 0.020

1.27 ± 0.212

0.4

0.49 ± 0.009

0.21 ± 0.022

0.60 ± 0.038

0.26 ± 0.072

0.6

0.58 ± 0.012

0.34 ± 0.040

0.69 ± 0.026

0.13 ± 0.027

1

0.64 ± 0.017

0.36 ± 0.021

0.75 ± 0.021

0.10 ± 0.017

5

0.66 ± 0.012

0.48 ± 0.015

0.82 ± 0.022

0.19 ± 0.047

10

0.68 ± 0.012

0.64 ± 0.012

0.90 ± 0.012

0.07 ± 0.016

  1. Doses of trastuzumab (Tzmab) and tamoxifen (Tam) in μg/ml and μM, respectively. Each value is the mean of three independent experiments (with eight replicate wells for each treatment) ± standard error.
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Breast Cancer Research

ISSN: 1465-542X

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