Figure 1
From: HER3 and downstream pathways are involved in colonization of brain metastases from breast cancer
Immunohistochemical profile of primary breast and brain metastases. A - Immunohistochemical analysis of matched primary breast and brain metastases. The graph depicts percentages of positive cases in each category. ER and PR were considered positive when >10% cells showed staining, HER2 was considered positive when IHC showed 3+ staining (>30% positive cells) or CISH showed gene amplification. Triple negative tumors were negative for ER, PR and HER2. CD44+/CD24- immunohistochemistry was assessed on serial sections and positivity was expression in >10% cells. B - Breakdown of basal markers. A tumor was regarded as basal if any of the following markers were positive (CK5/6, CK14, CK17, p63, SMA, and EGFR) with >10% cells showed staining.