Table 3 Unadjusted models for DFS and OS¹

CYP2B6

Any variant vs. All WT

1.10 (0.83, 1.46)

0.51

1.12 (0.83, 1.52)

0.46

CYP2C9

Any variant vs. All WT

0.97 (0.72, 1.29)

0.82

1.01 (0.75, 1.37)

0.94

CYP2D6

G/A vs. A/A

1.07 (0.57, 2.03)

0.83

1.30 (0.64, 2.62)

0.46

G/G vs. A/A

0.89 (0.48, 1.65)

0.72

1.01 (0.51, 1.99)

0.98

CYP3A4

*1B/*1A vs. *1A/*1A

1.70 (1.10, 2.63)

0.02

1.21 (0.74, 1.96)

0.45

*1B/*1B vs *1A/*1A

1.96 (0.96, 3.98)

0.07

1.64 (0.77, 3.50)

0.20

CYP3A5

*3/*1 vs. *1/*1

0.76 (0.36, 1.59)

0.47

1.18 (0.49, 2.84)

0.72

*3/*3 vs. *1/*1

0.74 (0.38, 1.45)

0.38

1.18 (0.52, 2.67)

0.69

CYP3A5

*6/*1 vs. *1/*1

2.71 (1.01, 7.32)

0.05

2.47 (0.92, 6.66)

0.07

GSTM1

Null vs. Non-null

0.71 (0.54, 0.93)

0.02

0.71 (0.53, 0.94)

0.02

GSTT1

Null vs. Non-null

1.41 (1.00, 1.97)

0.05

1.31 (0.91, 1.88)

0.14

GSTP1

Any Var vs. All WT

1.03 (0.79, 1.36)

0.81

1.18 (0.88, 1.57)

0.27

CYP-GST genotype groups

Unfavorable vs. Intermediate or Favorable

1.29 (0.97-1.72)

0.08

1.32 (0.98-1.79)

0.07

Lymph node

Continuous

1.02 (1.00, 1.04)

0.06

1.02 (1.00, 1.04)

0.10

Tumor size

Continuous

1.00 (1.00, 1.01)

0.36

1.00 (1.00, 1.01)

0.13

Age

Continuous

0.99 (0.97, 1.00)

0.10

0.99 (0.97, 1.01)

0.28

ER

Pos vs. Neg

0.79 (0.60, 1.04)

0.10

0.78 (0.58, 1.04)

0.10

PR

Pos vs. Neg

0.82 (0.62, 1.07)

0.15

0.88 (0.66, 1.17)

0.37

Race

Black vs. White

1.44 (0.84, 2.48)

0.19

1.41 (0.80, 2.49)

0.23

Other vs. White

1.49 (0.83, 2.68)

0.18

1.20 (0.64, 2.28)

0.57

Arm

CAF+HDC vs. CAF

0.79 (0.60, 1.03)

0.08

0.93 (0.70, 1.23)

0.59