Figure 1From: Potential prognostic value of heat-shock protein 90 in the presence of phosphatidylinositol-3-kinase overexpression or loss of PTEN, in invasive breast cancersImmunohistochemical analyses of various signaling molecules in MAPK and PI3K pathways. Representative examples of immunohistochemical staining patterns observed in invasive breast cancers. p-AKT (a) shows predominant nuclear staining with weak cytoplasmic staining in this case. PI3K-p110α (b), p-S6 (c), p-RAF (d), and HSP90 (e) show strong cytoplasmic staining. The p-p70S6K (f), p-p44/42 MAPK (g), and PTEN (h) are localized in both cytoplasmic and nuclear compartments.Back to article page