From: MicroRNAs and their target gene networks in breast cancer
miRNA | Target | Functional pathway | Reference |
---|---|---|---|
Tumor suppressor miRNAs | Â | Â | Â |
   miR-206 | ESR1 | ER signaling | |
   miR-17-5p | AIB1, CCND1, E2F1 | Proliferation | |
   miR-125a, b | HER2, HER3 | Anchorage-dependent growth | |
   miR-200 | BMI1, ZEB1, ZEB2 | TGF-β signaling | |
   let-7 | H-RAS, HMGA2, LIN28, PEBP1 | Proliferation, differentiation | |
   miR-34a | CCND1, CDK6, E2F3, MYC | DNA damage, proliferation | |
   miR-31 | FZD3, ITGA5, M-RIP, MMP16, RDX, RHOA | Metastasis | [61] |
Oncogenic miRNAs | Â | Â | Â |
   miR-21 | BCL-2, TPM1, PDCD4, PTEN, MASPIN | Apoptosis | |
   miR-155 | RHOA | TGF-β signaling | [68] |
   miR-10b | HOXD10 | Metastasis | [69] |
   miR-373/520c | CD44 | Metastasis | [79] |