From: BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A
Cell line
nM DZNep (SEM)
BRCA1-proficient
KP-6.3
3523 (463)
BRCA1-reconstituted
KB1PR-3.12 E3
1954 (744)
KB1PR-3.12 F4
829 (331)
BRCA1-deficient
KB1P-3.12
135 (13)
KB1P40.1
187 (33)
Ratio (BRCA1-reconst. vs. deficient)
8.7*
Significance
0.003