Cell line | nM DZNep (SEM) | nM TSA (SEM) |
---|
BRCA1-proficient
| Â | Â |
KP-3.33 | 3202 (284) | 27 (1.2) |
KP-6.3 | 3467 (277) | 35 (1.5) |
KP-7.7 | 2163 (63) | 25 (3.8) |
BRCA1-deficient
| Â | Â |
KB1P-3.12 | 154 (14) | 26 (2.4) |
KB1P-30.3 | 163 (13) | 17 (0.6) |
KB1P-40.1 | 171 (9) | 36 (3.4) |
Ratio (KP/KB1P)
| 18.1* | 1.1 |
Significance
| < 0.0001 | 0.5 |
- Note: Values between brackets represent the standard error of the mean (SEM) of at least three independent experiments. Ratio: Average half maximal inhibitory concentration (IC50) values of 3-deazaneplanocin A (DZNep) and trichostatin A (TSA) for the K 14cre;Brca1w.t/w.t; p 53F/F(KP) lines were compared with average IC50 values of the K 14cre; B rca 1F/F; p 53F/F(KB1P) lines. *Significance: P < 0.01 (t-test).