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Table 4 Frequency of molecular phenotypes among DCIS and invasive breast cancers, Nurses' Health Study (1976 to 1996)

From: Comparison of molecular phenotypes of ductal carcinoma in situand invasive breast cancer

Immunophenotype

DCIS (n = 272)

All invasive (n = 2249)

Infiltrating ductal, NOS only (n = 1550)

p valuea

p valueb

 

n (%)

n (%)

N (%)

  

Luminal A

170 (62.5)

1650 (73.4)

1053 (67.9)

0.0002

0.08

Luminal B

36 (13.2)

116 (5.2)

90 (5.8)

<0.0001

<0.0001

HER2+

37 (13.6)

128 (5.7)

107 (6.9)

<0.0001

<0.0001

Basal-like

21 (7.7)

245 (10.9)

223 (14.4)

0.15

0.005

Unclassified

8 (2.9)

110 (4.9)

77 (5.0)

0.15

0.14

  1. a p value from Chi-Squared test comparing DCIS to all invasive tumours.b p value from Chi-Squared test comparing DCIS to infiltrating ductal tumours. DCIS, ductal carcinoma in situ.