Cell line | Fa | Compound | IC50 (nmol/l) | DRI | CI |
---|
MCF7/Aro | 0.5 | AEW541 | 33 | 5.9 | 0.888 |
 |  | Letrozole | 158 | 1.6 |  |
 | 0.75 | AEW541 | 55 | 7.7 | 0.597 |
 |  | Letrozole | 265 | 2.4 |  |
 | 0.9 | AEW541 | 92 | 10.0 | 0.406 |
 |  | Letrozole | 445 | 3.6 |  |
T47D/Aro | 0.5 | AEW541 | 268 | 7.9 | 0.513 |
 |  | Letrozole | 13 | 3.0 |  |
 | 0.75 | AEW541 | 3326 | 10.0a
| 0.284 |
 |  | Letrozole | 166 | 4.4 |  |
- Combination index (CI) values above 1.1 indicate antagonistic, 0.9 to 1.1 additive, 0.7 to 0.9 moderately synergistic, 0.3 to 0.7 synergistic, and under <0.3 strongly synergistic. Note that the effective dose at 50%, 75% and 90% inhibition is decreased when both agents are combined. aDRI is greater than 10 (outside of concentration range). DRI, dose response index; Fa, fraction affected; IC50, 50% inhibitory concentration.