Table 8 Methylated primary ER-negative and ER-positive tumors: T1c and T2/T3 subgroups
| Â | T1c (n = 48) | T2/T3 (n = 82) | ||||
|---|---|---|---|---|---|---|
Gene | ER negative (n = 24) | ER positive (n = 24) | P valuea | ER negative (n = 41) | ER positive (n = 41) | P valuea |
RASSF1A | 13 (54%) | 21 (88%) | 0.011 | 23 (56%) | 39 (95%) | <0.0001 |
CCND2 | 10 (42%) | 20 (83%) | 0.0029 | 16 (39%) | 25 (61%) | 0.0468 |
GSTP1 | 3 (13%) | 6 (25%) | NS | 1 (2%) | 13 (32%) | 0.0004 |
TWIST | 6 (25%) | 12 (50%) | NS | 11 (27%) | 20 (49%) | 0.0404 |
APC | 9 (38%) | 8 (33%) | NS | 11 (27%) | 23 (56%) | 0.0071 |