Figure 1

microRNAs and PCGs: involvement in early (initiation), intermediate (progression) and late (metastasis) steps in tumorigenesis. Presented are the specific instances in which let-7 and miR-16 families (already found to be involved in early stages of tumorigenesis), and miR-21 and miR-221 proved to be involved in tumor progression. Also shown is the newly described balance between miR-10b, miR-373, miR-520c, and miR-335 in metastasis. The significant confirmed targets are also shown. miRNA, microRNA; PGC, protein-coding gene.