Cytoplasmic location of factor-inhibiting hypoxia-inducible factor is associated with an enhanced hypoxic response and a shorter survival in invasive breast cancer

Table 4 Univariate analysis of nuclear and cytoplasmic factor-inhibiting hypoxia-inducible factor 1 (FIH-1) expression with hypoxia-inducible factor 1α (HIF-1α) expression

	Nuclear FIH-1-positive (n = 186)	Nuclear FIH-1-negative (n = 109)	P value	Cytoplasmic FIH-1-positive (n = 197)	Cytoplasmic FIH-1-negative (n = 98)	P value
Nuclear HIF-1α			0.004			0.93
Negative	52	48		66	32
Positive	114	50		110	52
Cytoplasmic HIF-1α			0.68			0.03
Negative	129	72		130	68
Positive	33	21		43	10

ISSN: 1465-542X