Table 3 Unpaired t-test results comparing multiple features (including patient age, tumor volume, and numerous tissue parameter comparisons) for the 22 'benign' tumors and the 14 'malignant' tumors

Age (years)

Benign/malignant

44.0 ± 13.9/57.6 ± 13.6

0.006

Tumor volume (cm³)

Benign/malignant

1.0 ± 0.9/1.4 ± 0.7

0.13

Tumor tissue [S_tO₂] – baseline (%)

Benign/malignant

87.9 ± 10.1/89.9 ± 6.8

0.51

Tumor tissue [Hbt] – baseline (μM)

Benign/malignant

11.0 ± 6.0/11.0 ± 7.0

0.77

Reference tissue [S_tO₂] – baseline (%)

Benign/malignant

92.4 ± 5.3/93.5 ± 6.5

0.57

Reference tissue [Hbt] – baseline (μM)

Benign/malignant

8.0 ± 4.0/9.0 ± 5.0

0.74

Differential [S_tO₂] – baseline (%)

Benign/malignant

-6.1 ± 10.0/-4.1 ± 3.3

0.47

Differential [Hbt] – baseline (%)

Benign/malignant

12.1 ± 32.3/17.8 ± 19.7

0.56

Tumor [S_tO₂] contrast – baseline (%)

Benign/malignant

4.1 ± 4.6/2.8 ± 1.2

0.34

Tumor [Hbt] contrast – baseline (%)

Benign/malignant

16.6 ± 8.1/13.2 ± 9.7

0.27

Reference tissue [S_tO₂] contrast – baseline (%)

Benign/malignant

2.3 ± 1.1/2.3 ± 1.2

0.88

Reference tissue [Hbt] contrast – baseline (%)

Benign/malignant

11.7 ± 5.6/14.4 ± 8.7

0.27

Differential [S_tO₂] contrast – baseline (%)

Benign/malignant

1.7 ± 4.1/0.5 ± 1.4

0.32

Differential [Hbt] contrast – baseline (%)

Benign/malignant

4.8 ± 6.3/-1.2 ± 6.2

0.008

Tumor tissue [S_tO₂] – compression peak (%)

Benign/malignant

87.2 ± 11.4/88.6 ± 7.8

0.7

Tumor tissue [Hbt] – compression peak (μM)

Benign/malignant

10.0 ± 6.0/11.0 ± 7.0

0.58

Reference tissue [S_tO₂] – compression peak (%)

Benign/malignant

91.4 ± 6.9/92.2 ± 7.6

0.76

Reference tissue [Hbt] – compression peak (μM)

Benign/malignant

7.0 ± 4.0/8.0 ± 5.0

0.62

Differential [S_tO₂] – compression peak (%)

Benign/malignant

-6.2 ± 12.8/-4.2 ± 4.7

0.59

Differential [Hbt] – compression peak (%)

Benign/malignant

13.0 ± 33.7/22.6 ± 22.1

0.35

Tumor [S_tO₂] contrast – compression peak (%)

Benign/malignant

4.3 ± 4.2/3.6 ± 2.8

0.56

Tumor [Hbt] contrast – compression peak (%)

Benign/malignant

16.4 ± 7.9/14.0 ± 12.5

0.48

Reference [S_tO₂] contrast – compression peak (%)

Benign/malignant

2.8 ± 1.4/2.8 ± 2.2

0.97

Reference [Hbt] contrast – compression peak (%)

Benign/malignant

12.2 ± 6.1/16.7 ± 13.9

0.18

Differential [S_tO₂] contrast – compression peak (%)

Benign/malignant

1.6 ± 3.4/0.8 ± 1.7

0.45

Differential [Hbt] contrast – compression peak (%)

Benign/malignant

4.3 ± 6.3/-2.7 ± 6.8

0.004

Variation in differential [S_tO₂] (%)

Benign/malignant

0.1 ± 4.5/0.2 ± 2.1

0.96

Variation in differential [Hbt] (%)

Benign/malignant

-0.9 ± 12.0/-4.9 ± 8.3

0.29

Variation in differential [S_tO₂] – tumor (%)

Benign/malignant

-0.3 ± 1.4/-0.8 ± 2.1

0.41

Variation in differential [Hbt] – tumor (%)

Benign/malignant

0.2 ± 4.2/-0.8 ± 5.2

0.54

Variation in differential [S_tO₂] – reference (%)

Benign/malignant

-0.4 ± 0.6/-0.5 ± 1.3

0.79

Variation in differential [Hbt] – reference (%)

Benign/malignant

-0.4 ± 3.5/-2.3 ± 5.9

0.24

Differential variations of [S_tO₂] – compression peak (%)

Benign/malignant

0.1 ± 1.7/-0.3 ± 1.2

0.44

Differential variations of [Hbt] – compression peak (%)

Benign/malignant

0.6 ± 4.7/1.5 ± 4.4

0.57