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Figure 4 | Breast Cancer Research

Figure 4

From: Anticlusterin treatment of breast cancer cells increases the sensitivities of chemotherapy and tamoxifen and counteracts the inhibitory action of dexamethasone on chemotherapy-induced cytotoxicity

Figure 4

Effects of combined treatment with antisense clusterin oligonucleotide (ODNclu) and paclitaxel or doxorubicin on cytotoxicity of the MDA-MB-231 (a) and MCF-7 (b) cell lines. Cells were treated daily with 100 nM antisense ODNclu or clusterin mismatch control ODN (ODNc) for 2 days. After ODN treatment, the medium was replaced with medium containing 10-7 and 10-8 M paclitaxel or doxorubicin. Cell viability was determined by trypan blue exclusion test. Each data point represents the mean percentages of at least three independent experiments ± standard error of the mean. D, doxorubicin; P, paclitaxel. *p < 0.05; **p < 0.01; ***p < 0.001.

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Breast Cancer Research

ISSN: 1465-542X

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