Table 2 Concordance between PathVysion and other HER2-testing protocols
Comparison with PathVysion | κ coefficient* | Degree of agreement | Agreement (percentage) | Sensitivity (percentage) | Specificity (percentage) |
|---|---|---|---|---|---|
PharmDx | 1.000 | Excellent | 100 | 100 | 100 |
INFORM (at least six signals per nucleus) | 0.916 ± 0.058 | Excellent | 98 | 100 | 94 |
INFORM (at least five signals per nucleus) | 0.799 ± 0.085 | Good | 91 | 100 | 88 |
INFORM (more than four signals per nucleus) | 0.532 ± 0.111 | Moderate | 76 | 100 | 57 |
CISH (at least six signals per nucleus) | 0.876 ± 0.070 | Excellent | 94 | 100 | 94 |
CISH (at least five signals per nucleus) | 0.762 ± 0.091 | Good | 89 | 100 | 88 |
In-house IHC (positive 3+, negative 0, 1+, 2+) | 0.792 ± 0.089 | Good | 91 | 89 | 91 |
In-house IHC (positive 3+, 2+, negative 0, 1+) | 0.475 ± 0.111 | Moderate | 72 | 100 | 57 |
HercepTest (positive 3+, negative 0, 1+, 2+) | 0.645 ± 0.104 | Good | 83 | 89 | 80 |
HercepTest (positive 3+, 2+, negative 0, 1+) | 0.350 ± 0.119 | Poor | 64 | 94 | 49 |