Table 1 Functional network generated by Ingenuity knowledge database analysis
Hub gene | Score | GATMs | Top functions |
|---|---|---|---|
TNF↑ | 34 | 35 | Lipid metabolism, small molecule biochemistry, cell death |
IFNG↑ | 34 | 35 | Lipid metabolism, molecular transport, small molecule biochemistry |
IL1B↑ | 34 | 35 | Immune response, cellular movement, haematological system development and function |
MYC↑ | 34 | 35 | Cell cycle, cellular movement, cancer |
CCL2↑, KDR↓, VEGF↓ | 34 | 35 | Cellular movement, cancer, tumour morphology |
SRC↑ | 34 | 35 | Haematological system development and function, immune and lymphatic system development and function, tissue morphology |
BCL2↑ | 34 | 35 | Cancer, cell death, cell morphology |
AGT↓ | 34 | 35 | Cell-to-cell signalling and interaction, haematological system development and function, immune and lymphatic system development and function |
TIMP1↑, EDN1↓ | 34 | 35 | Cancer, cellular movement, cellular development |
LEP↓ | 34 | 35 | Lipid metabolism, molecular transport, small molecule biochemistry |
AR↓ | 34 | 35 | Cellular growth and proliferation, gene expression, cellular development |
IGF2↓, ERBB3↑ | 34 | 35 | DNA replication, recombination, and repair, cancer, cell cycle |
HOXA9↓, CDH1↑ | 34 | 35 | Cellular growth and proliferation, cell death, cancer |
ARNT2↑, ZAP70↑ | 34 | 35 | Cellular growth and proliferation, haematological system development and function, immune response |
PPARA↓, IL6, SERBF1 | 15 | 24 | Lipid metabolism, small molecule biochemistry, molecular transport |
CDC42, RAC1 | 13 | 22 | Cell signalling, free radical scavenging, nucleic acid metabolism |
ERBB2↑ | 12 | 17 | Cancer, tumour morphology, cell cycle |
FN1 | 12 | 21 | Cell-to-cell signalling and interaction, cellular movement, reproductive system development and function |
FOS | 12 | 21 | Gene expression, cell cycle, haematological system development and function |
IGF1, CCND1, BMP2 | 12 | 21 | Cellular growth and proliferation, connective tissue development and function, skeletal and muscular system development and function |
IL4 | 12 | 21 | Cellular assembly and organization, cell cycle, DNA replication, recombination, and repair |
NFYB | 11 | 16 | Cancer, cell cycle, cellular assembly and organization |
IL13, MAPK8, NFKB1 | 11 | 20 | Haematological system development and function, immune and lymphatic system development and function, tissue morphology |
STAT3, INSR, PTPN | 11 | 20 | Cellular growth and proliferation, haematological system development and function, immune response |
NFKBIA, CD40LG, HGF | 11 | 20 | Cell death, cellular movement, haematological system development and function |
KRAS, CDKN1A | 10 | 19 | Cellular growth and proliferation, cell signalling, cancer |
TNF↑ | 10 | 19 | Carbohydrate metabolism, molecular transport, small molecule biochemistry |