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Table 1 Mammary tumor incidence in WapInt6sh female transgenic mice compared with wild-type female FVB/N mice at 24 months of age.

From: Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis

Strain and genotype No. of mice with tumors Total mice (N) Tumor incidence (%) Fisher's exact test p value Reference
FVB/N wild-typea 0 71 0 <0.00001b [17]
FVB/N wild-type, multiparousc 0 22 0 0.0006d [16]
FVB/N WapInt6sh virgins 1e 26f 3.8% 0.0016g This work
FVB/N wild-type, multiparoush 0 8 0 0.035i This work
FVB/N WapInt6sh, multiparous 10j 24k 41.7% NA This work
  1. aReported by the National Institute for Environmental Health Sciences. For this comparison, only histological malignant lesions were scored as tumors; adenomas and other benign lesions were not included.
  2. bp < 0.00001 from the Fisher's exact test of previously published tumor incidence in FVB/N wild-type mice vs WapInt6sh multiparous females (row 1 vs row 5).
  3. cIncludes all frank tumors classified histopathologically as adenomas or adenocarcinomas.
  4. dp = 0.0006 from the Fisher's exact test of previously published tumor incidence in FVB/N wild-type multiparous mice vs WapInt6sh multiparous females (row 2 vs row 5).
  5. eHistologically, a papillary adenocarcinoma
  6. fTotal mice included 21 heterozygous and 5 homozygous WapInt6sh transgenic mice from J1 founder line that survived 24 months or longer.
  7. gp = 0.0016 from the Fisher's exact test of WapInt6sh virgins vs WapInt6sh multiparous females (row 3 vs row 5).
  8. hIncludes multiparous FVB/N wild-type littermates resulting from WapInt6sh heterozygous crosses. Each mouse is identified in Additional file 3.
  9. ip = 0.035 from the Fisher's exact test of wild-type multiparous vs WapInt6sh multiparous females (row 4 vs row 5).
  10. jOf the 11 tumors arising in 10 multiparous transgenic females, there were 4 undifferentiated tumors, 5 papillary adenocarcinomas and 2 glandular adenocarcinomas.
  11. kTotal mice included both heterozygous or homozygous WapInt6sh transgenic mice from J1 founder line that lived to tumor age (>12 months) and produced >1 litter.