Table 1 Clinical and histopathological characteristics of cases included in the study
From: TP53mutation status and gene expression profiles are powerful prognostic markers of breast cancer
All cases (n = 212) | Microarray (n = 80) | |||
|---|---|---|---|---|
Characteristics | Number | Percent | Number | Percent |
Age (year) | ||||
<45 | 24 | 11.3 | 6 | 7.5 |
45–55 | 37 | 17.5 | 12 | 15.0 |
55–65 | 38 | 17.9 | 20 | 25.0 |
65–75 | 50 | 23.6 | 21 | 26.3 |
≥75 | 63 | 29.7 | 21 | 26.3 |
Gender | ||||
Female | 211 | 99.5 | 79 | 98.8 |
Male | 1 | 0.5 | 1 | 1.2 |
Type | ||||
Ductal | 132 | 64.4 | 51 | 63.8 |
Lobular | 53 | 25.8 | 22 | 27.5 |
Mucinous | 8 | 3.9 | 3 | 3.8 |
Medullary | 4 | 2.0 | 0 | 0 |
DCIS with microinvasion | 1 | 0.5 | 1 | 1.3 |
Tubulolobular | 2 | 1.0 | 2 | 2.5 |
Other | 5 | 2.4 | 1a | 1.3 |
Unknown | 7 | 0 | ||
Tumor size | ||||
pT1 (≤2 cm) | 71 | 34.6 | 20 | 26.0 |
pT2 (>2 ≤5 cm) | 112 | 54.6 | 44 | 57.1 |
pT3 (>5 cm) | 15 | 7.3 | 8 | 10.4 |
pT4 (infiltrating growth) | 7 | 3.4 | 5 | 6.5 |
Unknown | 7 | 3 | ||
Node status | ||||
pN0 (negative) | 95 | 44.8 | 33 | 41.3 |
pN1 (1–3 positive) | 48 | 22.6 | 23 | 28.8 |
pN2–N3 (≥4 positive) | 33 | 15.6 | 12 | 15.0 |
pNX (Nodes not removed) | 36 | 17.0 | 12 | 15.0 |
Grade | ||||
1 | 19 | 9.0 | 6 | 7.5 |
2 | 141 | 66.5 | 53 | 66.3 |
3 | 48 | 22.6 | 21 | 26.3 |
Unknown | 4 | 0 | ||
Estrogen receptor | ||||
Positive | 109 | 57.7 | 45 | 62.5 |
Negative | 80 | 42.3 | 27 | 37.5 |
Unknown | 23 | 8 | ||
Progesteron receptor | ||||
Positive | 130 | 62.8 | 51 | 67.1 |
Negative | 77 | 37.2 | 25 | 32.9 |
Unknown | 5 | 4 | ||
TP53 mutation | ||||
Mutation | 48 | 23.6 | 20 | 25.0 |
Wild type | 155 | 76.4 | 60 | 75.0 |
Unknown | 9 | 0 | ||
Gene expression group | ||||
Luminal A | 23 | 28.8 | ||
Highly proliferating luminal | 15 | 18.8 | ||
Normal-like | 20 | 25.0 | ||
Basal-like | 12 | 15.0 | ||
ERBB2+ | 10 | 12.5 | ||
Adjuvant therapy | ||||
Radiation therapy | ||||
Yes | 60 | 31.1 | 25 | 32.9 |
No | 133 | 68.9 | 51 | 67.1 |
Unknown | 19 | 4 | ||
Chemotherapyb | ||||
Yes | 27 | 12.9 | 11 | 14.1 |
No | 182 | 87.1 | 67 | 85.9 |
Unknown | 3 | 2 | ||
Hormonal treatmentc | ||||
Yes | 53 | 25.1 | 25 | 31.6 |
No | 158 | 74.9 | 54 | 68.4 |
Unknown | 1 | |||
Recurrence (distant metastisis) | ||||
Positive | 72 | 34.1 | 34 | 42.5 |
Negative | 139 | 65.9 | 46 | 57.5 |
Unknown | 1 | 0 | ||
Status | ||||
Alive | 75 | 37.5 | 25 | 32.5 |
Dead of disease | 63 | 31.5 | 30 | 39.0 |
Dead of other cause | 60 | 30.0 | 20 | 26.0 |
Emmigrated | 2 | 1.0 | 2 | 2.6 |
Unknown | 12 | 3 | ||