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Table 2 Frequencies of contralateral breast cancer patients CBC carrying apathogenic DNA-damage repair pathway mutation

From: Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study

Parameter

Breast cancer < 50 yearsa (percentage)

All CBC patients (n = 247)

Previous RT (n = 169)

No RT (n = 78)

Carriers versus non-carriers

  

n

Percentage

n

Percentage

n

Percentage

OR for CBC after RT

95% CI

p

DDRP mutated

~10

51

21

41

24.3

10

12.8

2.18

1.03–4.62

0.043

CHEK2

1–2

15

6.1

13

7.7

2

2.6

3.17

0.69–14.39

 

BRCA1

~4–5

27

11.3

20

11.8

7

9

1.36

0.55–3.37

 

BRCA2

~0.5–1

5

2

4

2.4

1

1.3

1.87

0.21–16.98

 

ATM truncating

~1–2

4

1.6

4

2.4

0

0

-

-

 
      

1b

1.3

1.87

0.21–16.98

 
  1. Results for all contralateral breast cancer (CBC) patients, and patients stratified by previous radiation exposure, are presented. Odds ratio (OR) and 95% confidence interval (CI) are given for mutation carriers versus non-carriers to develop radiation-associated breast cancer. DDRP, DNA-damage repair pathway; RT, radiation treatment. aPublished results; bHypothetical assumption of one case.
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Breast Cancer Research

ISSN: 1465-542X

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