A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study

Table 3 PTGS2 haplotypes and breast cancer risk in the Nurses' Health Study

Haplotype	Cases (percentage)	Controls (percentage)	OR (95% CI)^a
z1 G-G-T-T-A	1,250 (49.4)	1,691 (48.2)	1.00 (reference)
z2 G-G-T-C-A	435 (17.2)	667 (19.0)	0.84 (0.72–0.98)
z3 G-C-T-T-A	403 (15.9)	544 (15.5)	0.99 (0.85–1.17)
z4 C-G-G-C-A	358 (14.1)	507 (14.5)	0.92 (0.79–1.09)
z5 C-G-G-C-G	53 (2.1)	63 (1.8)	1.16 (0.78–1.72)
			Global p = 0.15

^aUnconditional logistic regression controlled for age, BMI at age 18 years, menopausal status at diagnosis, history of benign breast disease, and family history of breast cancer. CI, confidence interval; OR, odds ratio; PTGS2, prostaglandin endoperoxide synthase 2.

ISSN: 1465-542X