MUC1 promoter sequence. (a) GATA cis-elements map identified in MUC1 promoter region. (b) DNA sequence showing the TATA box (white box), the transcriptional start site +1 (TSS arrow) and the open reading frame (ORF arrow). Gray boxes indicate putative binding sites for GATA transcription factors showing the following: a GATA1 sequence (-448), a GATA3 sequence (-2395) and four GATA-like sequences (-1446, -1574, -2472, and -2604). Known regulatory elements are underlined (Sp1, STAT1/3, E-MUC1).