|  | Rosner, Colditz and Willett [19] | ||
---|---|---|---|---|
Rate of tissue aging | Pike et al. [18] | One-birth model | Two births | Multiple births |
Menarche to first birth | 1.0 | 1.0 | 1.0 | 1.0 |
After first birth, before menopause | 0.70 | 0.67 (p < 0.001) | 0.84 (p = 0.19) | 0.79 (p = 0.002) |
After second birth | Â | Â | 0.68 (p = 0.20) | 0.03a (p = 0.02) (per year from birth to menopause, for each birth) |
After menopause | 0.105 | 0.43 (p = 0.002) | 0.43 (p = 0.002) | 0.46b(p = 0.002) |
Increase at first birth (years) | 2.2 | 7.45 (p < 0.001) | 6.4 (p = 0.02) | 7.61 (p < 0.001) |
Increase at second birth | Â | Â | -0.02 (p = 0.99) | -1.69 |
K | Fixed at 4.5 | 2.9 (2.5–3.3) | 2.8 (2.4–3.2) | 2.8 (2.4–3.2) |