Figure 5From: Dehydroepiandrosterone inhibits the progression phase of mammary carcinogenesis by inducing cellular senescence via a p16-dependent but p53-independent mechanismA hypothetical model of inhibition of mammary carcinogenesis by DHEA. Our data indicate that DHEA, by increasing p16 and p21 expression, may suppress cell proliferation and induce senescence and apoptosis. The arrows indicate the changes in the corresponding parameters.Back to article page