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Table 3 Downregulated genes in MCF-7 cells after exposure to rapamycin plus CN-A for 12 hours

From: Effects of combined treatment with rapamycin and cotylenin A, a novel differentiation-inducing agent, on human breast carcinoma MCF-7 cells and xenografts

  

Gene expression ratio

GenBank number

Gene name

Rapamycin + CN-A

Rapamycin

CN-A

XM_097230.3

Similar to Cerebellin-like glycoprotein 1 (LOC147381)

0.15

0.93

0.22

NM_006417.2

Interferon-induced protein 44 (IFI44)

0.18

0.62

0.24

XM_095568.5

Hypothetical protein DKFZp762C1112 (DKFZp762C1112)

0.19

1.13

0.29

NM_006820.1

Chromosome 1 open reading frame 29 (C1orf29)

0.20

0.83

0.21

NM_004430.1

Early growth response 3 (EGR3)

0.21

0.53

0.19

NM_024563.1

Hypothetical protein FLJ14054 (FLJ14054)

0.22

0.52

0.45

NM_017816.1

Hypothetical protein FLJ20425 (LYAR)

0.28

0.44

0.45

NM_004934.2

Cadherin 18, type 2 (CDH18)

0.28

1.10

0.20

NM_152454.1

Hypothetical protein FLJ31461 (FLJ31461)

0.29

1.11

0.29

XM_084501.3

Hypothetical protein LOC143381 (LOC143381)

0.29

1.36

0.24

NM_004704.1

RNA, U3 small nucleolar interacting protein 2 (RNU3IP2)

0.30

0.61

0.65

NM_006993.1

Nucleophosmin/nucleoplasmin, 3 (NPM3)

0.32

0.48

0.47

NM_003504.2

CDC45 cell division cycle 45-like (S. cerevisiae) (CDC45L)

0.32

0.48

0.69

XM_059689.2

Similar to agCP15329 (LOC134111)

0.34

0.69

0.38

NM_015179.1

KIAA0690 protein (KIAA0690)

0.35

0.56

0.71

NM_014520.1

MYB binding protein (P160) 1a (MYBBP1A)

0.35

0.53

0.62

XM_300777.1

Similar to muscle protein (LOC348523)

0.35

0.70

0.69

NM_032509.1

RNA binding protein (LOC84549)

0.35

0.47

0.75

NM_014503.1

Downregulated in metastasis (DRIM)

0.36

0.48

0.56

NM_000269.1

Nonmetastatic cells 1, protein (NM23A) expressed in (NME1)

0.37

0.58

0.65

XM_050219.6

Synaptopodin 2 (SYNPO2)

0.37

0.93

0.57

XM_295865.1

LOC340895 (LOC340895)

0.37

1.34

0.33

NM_133263.1

PPAR gamma coactivator 1β(PERC)

0.37

0.62

0.74

NM_002220.1

Inositol 1,4,5-trisphosphate 3-kinase A (ITPKA)

0.37

0.60

0.62

NM_015068.1

Oaternally expressed 10 (PEG10)

0.38

0.77

0.43

  1. CN-A, cotylenin A.