Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2mutation carriers

Breast Cancer Research

Table 3 Weight change and subsequent cancer risk: subjects stratified by their age at diagnosis of cancer

Weight change between age 18 and 30 years	Cases (number)	Controls (number)	OR^a (95% CI)	P	P for trend
In all subjects^b	966	966
Loss of at least 10 pounds	53	81	0.66 (0.46–0.93)	0.03
Loss of <10 to gain of ≤ 10 pounds	536	542	1 (referent)
Gain of 10 to ≤ 20 pounds	227	190	1.19 (0.96–1.49)	0.12
Gain of > 20 pounds	150	135	1.00 (0.77–1.30)	0.99	0.46
According to case subjects' age at diagnosis
>30 to ≤ 40 years^c	478	478
Loss of at least 10 pounds	23	49	0.47 (0.28–0.79)	0.005
Loss of <10 to gain of ≤ 10 pounds^d	255	254	1 (referent)
Gain of 10 to ≤ 20 pounds	112	89	1.25 (0.91–1.71)	0.17
Gain of >20 pounds	88	86	1.03 (0.72–1.47)	0.88	0.48
>40 years^d	488	488
Loss of at least 10 pounds	30	32	0.97 (0.52–1.65)	0.91
Loss of <10 to gain of ≤ 10 pounds^d	281	288	1 (referent)
Gain of 10 to ≤ 20 pounds	115	101	1.16 (0.85–1.59)	0.36
Gain of >20 pounds	62	67	0.95 (0.64–1.43)	0.82	0.75

Subjects were women with a deleterious mutation in BRCA1 or BRCA2 who did (case subjects) or did not (control subjects) receive a diagnosis of cancer. ^aAll odds ratios (ORs) were derived using univariate conditional logistic regression. ^bExcludes case subjects diagnosed at age ≤ 30 years. ^cExcludes case subjects diagnosed at age ≤ 30 and >40 years. ^dExcludes case subjects diagnosed at ≤ 40 years. CI, confidence interval.

ISSN: 1465-542X