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Table 1 Likelihood ratios for the S384F variant

From: Strong evidence that the common variant S384F in BRCA2has no pathogenic relevance in hereditary breast cancer

  LR for S384F (BRCA2)
Co-segregation 3.236
Co-occurrence 0.00000111
Loss of heterozygosity 0.00391
Overall LR 1.4 × 10-8
  1. An overall likelihood ratio (LR) of <0.01 is considered to prove that the variant is neutral [3].