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Table 6 Univariate and multivariate analysis of factors predicting postrelapse survival

From: Phosphorylation of estrogen receptor α serine 167 is predictive of response to endocrine therapy and increases postrelapse survival in metastatic breast cancer

  Univariate Multivariate
Factor P RR 95% CI P RR 95% CI
Age 0.67 0.882 0.494–1.576    
Tumor size 0.21 1.483 0.797–2.759    
Lymph node status 0.40 0.746 0.376–1.479    
Histological grade 0.20 0.542 0.213–1.382    
HER2 0.0033* 0.340 0.166–0.699    
ER-α (1D5) 0.0009* 2.924 1.550–5.515 0.0076* 2.465 1.271–4.781
ER-α Ser118 0.36 1.308 0.732–2.340    
ER-α Ser167 0.035* 1.890 1.045–3.420 0.19 1.536 0.841–2.900
ER-β1 0.37 1.355 0.697–2.635    
ER-βcx/β2 0.10 1.627 0.905–2.926    
PR (636) 0.0012* 2.796 1.498–5.220    
PRA 0.03* 2.182 1.202–3.960    
PRB 0.013* 2.157 1.177–3.951 0.24 1.499 0.763–2.945
  1. CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; RR, relative risk. *P < 0.05.