Figure 3

A schematic diagram for the Notch signaling pathway. Upon binding of the DSL ligand, Notch signaling is modulated by fringe, and Notch receptors are activated by serial cleavage events involving members of the ADAM (for 'a disintegrin and metalloproteinase') protease family, as well as an intramembrane cleavage regulated by γ-secretase (presenilin). This intramembrane cleavage is followed by translocation of the intracellular domain on Notch to the nucleus, where it acts on downstream targets. CBF, C promoter binding factor; HDAC, histone deacetylase; HAT, histone acetyltransferase.