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Fig. 5 | Breast Cancer Research

Fig. 5

From: MUC16 promotes triple-negative breast cancer lung metastasis by modulating RNA-binding protein ELAVL1/HUR

Fig. 5

MUC16-associated HuR targets in TNBC. A. Scatter plot of human metastasis array after RIP assay with HuR antibody indicating the MUC16-associated HuR target genes in TNBC cells. Scatter plot showing upregulation of Myc, EWSR1, VEGFA, RPLP, NF2, and CHD4 in scramble (HCC1806-SCR) cells; while ETV4, CXCR2, RORB, and CD82 genes were downregulated in the MUC16 knockdown (HCC1806-shMUC16) cells. B, C. Western blot showing decreased levels of cMyc and YBX-1 expression upon MUC16 knockdown. D, E. Represents that MS-444 treatment and its effect on migration properties of HCC1806 and MDA MB 231 cells. F. Western blot showing decreased expression of cMyc upon MS-444 treatments in HCC1806 and MDA MB 231 cell lines. G, H. TCGA-METABRIC analysis indicated co-expression of HuR and Myc in breast cancer and TNBC subtype

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Breast Cancer Research

ISSN: 1465-542X

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