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Fig. 1 | Breast Cancer Research

Fig. 1

From: Fluid flow exposure promotes epithelial-to-mesenchymal transition and adhesion of breast cancer cells to endothelial cells

Fig. 1

a Heat map of differentially expressed genes between static and flow-exposed MDA-MB-231, BT-474, SK-BR-3 and MCF-7 breast cancer cells; b Number of differentially expressed genes between static and flow-exposed breast cancer cells (fold change ≥ 1.5 and p ≤ 0.01); Exposure of breast cancer cells to fluid flow enriched molecular processes involved in metastatic progression, including Regulation of Epithelial-to-Mesenchymal Transition (c), Positive regulation of cell motility (d), Positive regulation of cell–cell adhesion (e), and Regulation of cell–matrix adhesion (f). GO categories with enrichment scores ≥ 2 and p ≤ 0.05 were considered statistically significant. For each cell type, microarrays were run for 3 biological replicates of static and flow-exposed cells

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