Table 4 Hazard ratios for incident CAD events in interaction models adjusted for baseline mediators

With BMI*

PRS

1.31 (1.18, 1.46)

1.5 × 10^–7

log(BMI)

1.24 (1.12, 1.37)

2.0 × 10^–5

PRS*log(BMI)

1.07 (0.97, 1.18)

0.17

With smoking

PRS

1.24 (1.06, 1.44)

4.0 × 10^–3

Past smoker

1.26 (1.00, 1.58)

0.044

Current smoker

1.72 (1.31, 2.27)

9.1 × 10^–5

PRS*past smoker

1.23 (0.98, 1.53)

0.069

PRS*current smoker

1.03 (0.79, 1.34)

0.82