Skip to main content

Table 2 Age-adjusted univariate associations of baseline characteristics and incident CAD

From: Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study

Variable

Hazard Ratio (95% CI)

P value

PRS

1.36 (1.23, 1.50)

6.0 × 10–10

Sociodemographic

  

Log(IMD)

1.25 (1.08, 1.45)

1.9 × 10–3

Education Level*

  

GSCE or similar

0.65 (0.51, 0.82)

2.0 × 10–4

A-level or similar

0.60 (0.42, 0.85)

3.8 × 10–3

Graduate

0.50 (0.34, 0.74)

4.6 × 10–4

Lifestyle

  

Log(BMI)

5.11 (3.05, 8.6)

6.1 × 10–10

Smoking

  

Past

1.44 (1.16, 1.78)

8.2 × 10–4

Current

1.93 (1.50, 2.51)

4.8 × 10–7

Drinking††

0.63 (0.51, 0.76)

1.6 × 10–6

Medical

  

Age at menarche

0.98 (0.92, 1.05)

0.56

Parity (number of full-term pregnancies)

1.12 (1.05, 1.21)

7.6 × 10–4

Hormone replacement therapy

1.17 (0.96, 1.42)

0.11

Thyroid disease

1.16 (0.87, 1.54)

0.29

Oncotherapy

  

Chemotherapy

1.02 (0.81, 1.28)

0.87

Radiotherapy

0.93 (0.75, 1.16)

0.53

Hormone therapy

0.84 (0.66, 1.07)

0.15

  1. All univariable models were fit to the same sample. All models adjusted for age, genotype array, and 8 genetic PCs
  2. *Education reference category is below GSCE
  3. Smoking reference category is never-smokers
  4. ††Drinking reference category is past-drinkers