- Research article
- Open Access
Abemaciclib plus fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in premenopausal women: subgroup analysis from the MONARCH 2 trial
Breast Cancer Research volume 23, Article number: 87 (2021)
In MONARCH 2, abemaciclib plus fulvestrant significantly improved median progression-free survival (PFS, 16.4 vs 9.3 months, hazard ratio [HR] 0.553) and overall survival (OS, 46.7 vs 37.3 months; HR 0.757) compared with placebo plus fulvestrant in hormone receptor-positive (HR-positive), human epidermal growth factor receptor 2-negative (HER2-negative) advanced breast cancer (ABC) patients who were endocrine therapy (ET) resistant, regardless of menopausal status. Here, we report findings in the premenopausal subgroup of the MONARCH 2 trial.
The premenopausal subgroup included patients with natural menstrual bleeding who received a gonadotropin-releasing hormone agonist at least 4 weeks prior to study treatment start date and for the entire study duration. Of the 669 patients enrolled in the MONARCH 2 trial, 114 were premenopausal (abemaciclib plus fulvestrant, n = 72; placebo plus fulvestrant, n = 42), and were included in this analysis. The primary objective was investigator-assessed PFS and secondary objectives were OS, objective response rate, and safety and tolerability. Exploratory analyses included time to second disease progression (PFS2), time to chemotherapy (TTC), and chemotherapy-free survival (CFS).
At the primary objective cutoff (February 14, 2017), median PFS was not reached for the abemaciclib plus fulvestrant arm versus 10.52 months for the placebo plus fulvestrant arm (HR 0.415; 95% CI 0.246–0.698). At the pre-specified OS interim cutoff (20-June-2019), median PFS was 28.6 months in the abemaciclib plus fulvestrant arm compared with 10.26 months in the placebo plus fulvestrant arm (HR 0.477; 95% CI 0.302–0.755). A numerical OS benefit was observed with abemaciclib plus fulvestrant compared to fulvestrant alone (HR 0.689; 95% CI 0.379–1.252, median, not reached vs 47.3 months). Improvements were also observed for the exploratory outcomes of PFS2 (HR 0.599), TTC (HR 0.674), and CFS (HR 0.642) with the addition of abemaciclib to fulvestrant. The safety profile was generally consistent with results disclosed previously.
Results of the premenopausal subgroup in the MONARCH 2 trial were consistent with the improved clinical outcomes observed in the intent-to-treat population. The analysis provides support for the use of abemaciclib plus fulvestrant (with ovarian suppression) as an effective treatment option for premenopausal patients with HR+, HER2- ABC who are ET-resistant.
Clinical trial registration: NCT02107703. Registered April 08, 2014- Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02107703.
In recent years, the incidence of advanced breast cancer (ABC) in women aged 25 to 39 years has slightly increased  and the disease is often more aggressive, with a poorer prognosis, and high rates of recurrence and mortality [2, 3]. Hence, there is growing interest in appropriate treatment strategies for pre-/perimenopausal women (hereafter referred to as premenopausal women) with hormone receptor-positive (HR +), human epidermal growth factor receptor 2-negative (HER2-) ABC [2, 4,5,6]. This population subgroup is often under-represented in clinical trials [3, 6, 7].
An optimal treatment approach in young women with HR+, HER2- ABC is still poorly defined and treatment strategies are usually derived from data from postmenopausal patients. Studies have highlighted that given the differences in tumor biology and quality of life, extending treatment options across patients with different menopausal status might not be the best strategy [2, 7, 8]. Additionally, there is the potential that these young women are at risk of over-treatment, based solely on age considerations .
Cyclin-dependent kinase 4 and 6 (CDK4 and 6) inhibitors have led to substantial improvements in progression-free survival (PFS) in the ABC setting, resulting in approval of CDK4 and 6 inhibitors in combination with ET or as monotherapy in ABC patients [10,11,12,13,14]. More recently, some studies have also demonstrated overall survival (OS) benefit, further establishing the effectiveness of these agents in the treatment of ABC [6, 15, 16]. Some of these [4, 5, 15] reported improved PFS in this premenopausal subgroup, leading to the recommendation of fulvestrant in combination with CDK4 and 6 inhibitors and ovarian suppression as a treatment option for premenopausal patients with HR+, HER2- ABC .
Abemaciclib is an oral, selective, and potent small molecule CDK4 and 6 dual inhibitor for the treatment of HR+, HER2- ABC that is dosed on a continuous schedule. Abemaciclib is currently approved in three indications in HR+, HER2- ABC; in combination with aromatase inhibitor for postmenopausal women as initial endocrine-based therapy (MONARCH 3) [12, 14], in combination with fulvestrant for women with disease progression following ET (MONARCH 2) , and as a single agent for patients with disease progression following ET and prior chemotherapy in the metastatic setting (MONARCH 1) [12, 14].
In the intent-to-treat (ITT) population (669 patients) of the MONARCH 2 trial, abemaciclib plus fulvestrant significantly improved investigator-assessed PFS compared with placebo plus fulvestrant in women with HR+, HER2- ABC who were ET-resistant (median PFS, 16.4 vs 9.3 months; hazard ratio [HR], 0.553; 95% confidence interval [CI], 0.449–0.681; P < 0.001) . Abemaciclib treatment resulted in improved objective response rate (ORR; 48.1% vs 21.3% in the control arm). The OS was significantly improved in the abemaciclib plus fulvestrant arm (median OS, 46.7 vs 37.3 months; HR 0.757; 95% CI 0.606–0.945; P = 0.01) . The addition of abemaciclib to ET led to consistent treatment benefit across subgroups including menopausal status. Here, we report the efficacy and safety results for the premenopausal patient subgroup from the MONARCH 2 trial.
Study design and patients
MONARCH 2 was a randomized, double-blind, phase III, trial of abemaciclib or placebo with fulvestrant in HR+, HER2- ABC women with any menopausal status (pre-, peri-, or post-menopausal) who had disease progression following ET. Patients were required to have disease that progressed while receiving prior ET (neoadjuvant or adjuvant ET, ≤ 12 months after completion of adjuvant ET, or while receiving first-line ET for metastatic disease). Patients with more than one ET or any prior chemotherapy for ABC were excluded. Full trial details and eligibility criteria were published previously .
This article presents the subanalysis of the premenopausal population which comprised patients with natural menstrual bleeding who received a gonadotropin releasing-hormone (GnRH) agonist, such as goserelin, at least 4 weeks prior to study treatment start date and for the entire study duration.
The study was approved by the ethical and local institutional review boards for the sites participating in the clinical trial, and was conducted in accordance with the Good Clinical Practice guidelines and the Declaration of Helsinki. All patients provided written informed consent before enrollment. This study was overseen by a steering committee, and safety data were evaluated quarterly by an independent data monitoring committee.
Details of the MONARCH 2 trial have been published previously . Briefly, patients received abemaciclib (150 mg) or placebo twice daily during each 28-day cycle plus 500 mg fulvestrant (per label). Treatment continued until progressive disease, death, or discontinuation for any other reason.
Efficacy and safety assessments
Safety analysis was performed on all patients who received at least one dose of study drug. Adverse events (AEs) were graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0, and were evaluated at every patient visit from baseline until follow-up.
The primary endpoint was investigator-assessed PFS as defined by Response Evaluation Criteria in Solid Tumors version 1.1, and measured from the time of randomized assignment until progressive disease or death (whichever was earlier). The secondary endpoints included OS (time of randomized assignment until death), ORR (proportion of patients with complete response or partial response [PR]), and safety and tolerability. Exploratory endpoints included: PFS2, defined as time from randomization to discontinuation of first subsequent post-discontinuation therapy or death (whichever was earlier), TTC, defined as time from randomization to initiation of first post-discontinuation chemotherapy (censoring patients who died prior to initiation of chemotherapy), and CFS, defined as time from randomization to initiation of first post-discontinuation chemotherapy or death (whichever was earlier).
The data cutoff for the primary analysis of PFS occurred on February 14, 2017. ORR, change in tumor size, and safety evaluations were also reported from the primary analysis. The data cutoff for the preplanned interim analysis of the key secondary endpoint of OS occurred on 20 June, 2019. At this interim data cutoff, PFS was updated and the exploratory endpoints of PFS2, TTC, and CFS were also evaluated descriptively.
All efficacy analyses were performed on the subgroup of premenopausal patients within the ITT population, corresponding to all premenopausal patients randomized to study treatment. For time-to-event endpoints, the Kaplan–Meier method was used to estimate the survival curve for each treatment group, and the Cox proportional hazard model was used to estimate the HR and corresponding 95% CI with an interaction term of menopausal status with treatment group. An exploratory mixed-model analysis was used to compare change in tumor size over time. Unless otherwise noted, all confidence intervals used a 95% confidence level. Safety was assessed in all premenopausal patients who received at least one dose of any study treatment (i.e. the safety population). The statistical analyses were performed using SAS (version 9.2 or later; SAS Institute, Cary, NC).
Patients and treatment
In the MONARCH 2 trial, 669 patients were randomly assigned to receive abemaciclib plus fulvestrant (n = 446) or placebo plus fulvestrant (n = 223). Of these, 114 patients (17.0%) were premenopausal (premenopausal population) and received ovarian suppression with a GnRH agonist. This included 72 patients in the abemaciclib plus fulvestrant arm, of whom 71 received study treatment, and 42 in the placebo plus fulvestrant arm.
Demographic and baseline characteristics were well-balanced between the two treatment arms (Table 1). At baseline, 60 patients (52.6%) presented with visceral disease and 34 (29.8%) with bone-only disease. A total of 43 patients (37.7%) had primary ET resistance (defined as relapse while on the first 2 years of adjuvant ET or PD within the first 6 months of first-line ET) .
At the primary PFS cutoff, a total of 40 (55.6%) patients in the abemaciclib plus fulvestrant arm and 11 (26.2%) patients in the placebo plus fulvestrant arm remained on treatment. The median number of cycles received was 17 in the abemaciclib plus fulvestrant arm and 11 in the placebo plus fulvestrant arm. At the data cutoff for interim OS analysis, 21 premenopausal patients (29.2%) in the abemaciclib plus fulvestrant arm versus four patients (9.5%) in the placebo plus fulvestrant arm were still receiving the study treatment. The median length of follow-up was approximately 4 years in each treatment arm (48.69 and 47.70 months in the abemaciclib plus fulvestrant and placebo plus fulvestrant arms, respectively).
At the time of the primary analysis cutoff, 28 (38.9%) versus 29 (69.0%) PFS events were observed and mPFS was not reached versus 10.52 months in the abemaciclib plus fulvestrant and placebo plus fulvestrant arms, respectively. The addition of abemaciclib to fulvestrant resulted in a meaningful improvement in PFS (HR 0.415; 95% CI 0.246–0.698), Fig. 1A. The PFS benefit was confirmed by blinded independent central review (HR 0.432; 95% CI 0.236–0.793).
At the interim OS analysis cutoff, 20 June 2019, the PFS analysis was updated. In the abemaciclib plus fulvestrant arm, 42 (58.3%) PFS events were observed versus 33 (78.6%) in the placebo plus fulvestrant arm. The median PFS achieved in the abemaciclib plus fulvestrant arm was 28.6 months compared with 10.26 months in the control arm (HR 0.477; 95% CI 0.302 to 0.755), Fig. 1B.
Objective response rate and tumor shrinkage
ORR was higher in the abemaciclib plus fulvestrant arm compared to the placebo plus fulvestrant arm (43.1%; 95% CI 31.6–54.5 vs 19.0%; 95% CI 7.2–30.9) (Table 2). This included two (2.8%) complete responses in the abemaciclib plus fulvestrant arm compared with no complete response in the placebo plus fulvestrant arm. Patients with measurable disease achieved an ORR of 60.8% (95% CI 47.4–74.2) in the abemaciclib plus fulvestrant arm and 28.6% (95% CI 11.8–45.3) in the placebo plus fulvestrant arm (P = 0.006). An exploratory analysis of mean change in tumor size demonstrated that after 12 cycles, tumor size in the abemaciclib plus fulvestrant arm decreased by 64.6% compared to 42.5% in the placebo arm.
At the interim OS cutoff, there were 25 (34.7%) versus 19 (45.2%) deaths and mOS was not reached versus 47.31 months in the abemaciclib plus fulvestrant versus placebo plus fulvestrant arms, respectively. A numerical OS benefit was observed with the addition of abemaciclib to fulvestrant (HR 0.689; 95% CI 0.379–1.252; Fig. 2) which was consistent with the ITT population.
At the interim OS analysis, a total of 88 patients had discontinued study treatment including 50 (69.4%) patients in the abemaciclib plus fulvestrant arm and 38 (90.5%) patients in the placebo plus fulvestrant arm. Forty-one (56.9%) patients in the abemaciclib plus fulvestrant arm compared to 35 (83.3%) patients in the placebo plus fulvestrant arm received a post-discontinuation therapy. Chemotherapy was received by 60 patients (n = 34, 47.2% patients vs n = 26, 61.9% patients in the abemaciclib plus fulvestrant and placebo plus fulvestrant arms, respectively) at any time post-discontinuation. ET was received by 48 patients (n = 26, 36.1% patients in the abemaciclib plus fulvestrant arm vs n = 22, 52.4% patients in the placebo plus fulvestrant arm), while 41 patients received a targeted therapy (n = 19, 26.4% patients in the abemaciclib plus fulvestrant arm vs n = 22, 52.4% patients in the placebo plus fulvestrant arm), and 17 patients received other therapies (n = 9, 12.5% patients in the abemaciclib plus fulvestrant arm vs n = 8, 19.0% patients in the placebo plus fulvestrant arm). Among those who received targeted therapies, 15 patients received CDK 4 and 6 inhibitor(s) as post-discontinuation therapy (n = 5, 6.9% patients in the abemaciclib plus fulvestrant arm vs n = 10, 23.8% patients in the placebo plus fulvestrant arm).
Other exploratory endpoints
With the addition of abemaciclib to fulvestrant, a clinically meaningful benefit was observed in other exploratory endpoints including PFS2 (HR 0.599; 95% CI 0.371–0.968; Fig. 3A), TTC (HR 0.674; 95% CI 0.404–1.124; Fig. 3B) and CFS (HR 0.642; 95% CI 0.398–1.037; Fig. 3C), consistent with ITT population.
Median PFS2 was 35.64 months in the abemaciclib plus fulvestrant arm versus 21.27 months in the placebo plus fulvestrant arm.
The median time to first chemotherapy treatment (censoring patients who died prior to receiving chemotherapy) was 50.24 months in the abemaciclib plus fulvestrant arm and 26.76 months in the placebo plus fulvestrant arm.
Deaths prior to receiving any chemotherapy were four (5.6%) patients in the abemaciclib arm and 4 (9.5%) patients in the placebo arm. Median CFS (including both chemotherapy and death as events) was 38.07 versus 19.07 months in the abemaciclib versus placebo arms, respectively.
The safety profile in the premenopausal subgroup was consistent to the ITT population. The most frequent adverse events of any grade were diarrhea (87.3% vs 23.8%), neutropenia (59.2% vs 7.1%) and leukopenia (43.7% vs 4.8%) in the abemaciclib plus fulvestrant versus placebo plus fulvestrant arms, respectively (Table 3). In the abemaciclib arm, key grade 3 adverse events of special interest were neutropenia (39.4%), leukopenia (16.9%), and diarrhea (11.3%). Serious adverse events were reported in eight patients (11.3%) in the abemaciclib plus fulvestrant arm and two patients (4.8%) in the placebo plus fulvestrant arm (Additional file 1: Supplemental Table 1).
Four patients (5.6%) discontinued study treatment due to an AE (neutropenia, diarrhea, drug-induced liver injury, and increased aspartate aminotransferase, n = 1 each). Twenty-eight (39.4%) patients in the abemaciclib versus 1 (2.4%) patient in the placebo arm had at least one dose reduction in abemaciclib/placebo due to an AE. In the abemaciclib arm, the AEs leading to dose reduction included neutropenia (n = 14, 19.7%), diarrhea (n = 12, 16.9%), nausea (n = 2, 2.8%), and lymphopenia n = 1, 1.4%).
No deaths due to AEs, during or within 30 days after treatment, occurred in the premenopausal population. At the primary PFS lock, one pre-menopausal subject was reported as death (within 30 days of treatment discontinuation) due to grade 5 embolism event reported as cerebral infarction. Later, at the OS interim lock, the investigator re-evaluated the primary death reason to be study disease.
MONARCH 2 study reported a large absolute OS benefit in a phase III clinical trial for HR+, HER2- ABC, regardless of menopausal status [6, 16]. In this report, we evaluated the treatment benefit of abemaciclib plus fulvestrant in the premenopausal subgroup of the MONARCH 2 trial. Our findings indicate that premenopausal patients with ET-resistant, HR+, HER2- ABC derived benefit from the addition of abemaciclib to fulvestrant, with outcomes broadly consistent with those in the overall ITT population.
In this subset study, PFS was prolonged in premenopausal subgroup (HR 0.415) with the addition of abemaciclib to fulvestrant. Additionally, the observed numerical OS benefit in this subgroup (HR 0.689) was consistent with findings from the ITT population (HR 0.757).
Improvements in favor of the abemaciclib arm were observed for all exploratory endpoints including PFS2, TTC and CFS, also consistent with the ITT population , further strengthening our understanding of the treatment benefit with abemaciclib. The improvement in PFS2 demonstrated the treatment effect of abemaciclib carried over beyond the first disease progression to the subsequent line of therapy, which is of clinical relevance. Treatment with abemaciclib delayed chemotherapy and the median TTC was almost doubled in the abemaciclib plus fulvestrant arm compared to placebo plus fulvestrant arm. Post-discontinuation therapy was well-balanced considering the number of patients remaining on study treatment in the abemaciclib plus fulvestrant arm. The higher percentage of patients receiving a post-discontinuation therapy in the placebo arm is linked to the fact that a higher percentage of patients on the placebo arm discontinued study treatment. Of note, although the difference in median TTC is substantial, the absolute median in each arm for TTC should not be over-interpreted due to a lack of adjustment for patient death, as patients who died prior to receiving chemotherapy were censored.
The safety profile of the premenopausal subgroup was similar to that of the ITT population. Overall, treatment was well-tolerated, and diarrhea associated with abemaciclib was generally predictable (occurred early), manageable (with conventional doses of antidiarrheal medication and dose reduction), and reversible. No differences in the safety profile were observed in premenopausal women compared to postmenopausal women in the overall population.
The effect of CDK4 and 6 inhibitors on premenopausal patients with ABC has been previously studied in two other trials. The combination of ribociclib plus ET (nonsteroidal aromatase inhibitor, ortamoxifen), evaluated in the MONALEESA-7 trial in a premenopausal population, demonstrated an improved PFS (median, 23.8 vs 13.0 months; HR 0.55; P < 0.0001)  and OS (HR 0.71; 95% CI 0.54–0.95; 4-year OS follow-up, HR 0.76; 95% CI 0.61–0.96) [6, 19]. In contrast, the PALOMA 3 trial evaluating another CDK4 and 6 inhibitor, palbociclib, in combination with fulvestrant did not demonstrate an OS benefit among premenopausal patients (HR 1.07; 95% CI 0.61 to 1.86; P = 0.25) . This finding was consistent with the results in the ITT population, where no OS benefit was observed.
Notably, patient population, inclusion criteria and prior treatments differed among the MONARCH 2, MONALEESA-7, and PALOMA-3 trials. The MONALEESA-7 trial only included premenopausal women with ≤ 1 line of prior chemotherapy for ABC and 40% had de novo metastases . The PALOMA-3 trial included both postmenopausal and premenopausal women, and 75% overall had prior ET or chemotherapy for ABC (prior ET, 46.1%; prior chemotherapy, 34.0%) . In the MONARCH 2 trial, postmenopausal and premenopausal women with no prior chemotherapy for ABC were enrolled, and 38% had 1 line of ET for ABC. These differences should be considered while interpreting and comparing results among these studies.
A potential limitation of this analysis is the limited sample size. Given that formal statistical testing was not planned within the premenopausal subgroup, the focus of this analysis was to estimate the key efficacy parameters and to describe the safety profile in this patient population. Therefore, these results within premenopausal patients need to be interpreted with caveats for the MONARCH 2 trial as well as in the context of any cross-trial comparisons. Nonetheless, we observed that the magnitude of the treatment benefit in the premenopausal subgroup is comparable to that in the ITT population, suggesting a clinically meaningful improvement. Follow-up is ongoing to further characterize the long-term benefit.
Current clinical guidelines recommend that patients with HR+, HER2- disease should be treated preferentially with ET, and chemotherapy reserved for rapidly progressing, or symptomatic disease. There is an unmet need for defined treatment guidelines in premenopausal breast cancer patients. Consistent with the ITT population, the benefit of abemaciclib plus fulvestrant was maintained across premenopausal women with HR+, HER2- ABC in the MONARCH 2 trial. The data support extending the use of abemaciclib plus endocrine therapy for the treatment of premenopausal women with endocrine-resistant disease.
Availability of data and materials
Eli Lilly and Company provides access to all individual participant data collected during the trial, after anonymization, except for pharmacokinetic or genetic data. Data are available to request 6 months after the indication studied has been approved in the USA and EU and after primary publication acceptance, whichever is later. No expiration date of data requests is currently set once data are made available. Access is provided after a proposal has been approved by an independent review committee identified for this purpose and after receipt of a signed data sharing agreement. Data and documents, including the study protocol, statistical analysis plan, clinical study report, and blank or annotated case report forms, will be provided in a secure data sharing environment. For details on submitting a request, see the instructions provided at http://www.vivli.org.
Advanced breast cancer
- CDK4 and 6:
Cyclin-dependent kinase 4 and 6
Human epidermal growth factor receptor 2-negative
Hormone receptor-positive, ITT, intent-to-treat
Objective response rate
Second disease progression
Time to chemotherapy
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We thank the patients, caregivers, and investigators who participated in the MONARCH 2 trial. All authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this manuscript to be published. Medical Writing support and editorial support, funded by Eli Lilly and Company, was provided by Anchal Sood and Antonia Baldo, respectively, from Syneos Health.
This work was funded by Eli Lilly and Company. The study sponsor provided the study drug and collaborated with the investigators to design the study; collect, analyze, and interpret the data; and write this report. The corresponding author had access to study data, and all authors approved submission for publication.
Ethics approval and consent to participate
The study was conducted in compliance with the ethical principles originating in or derived from the Declaration of Helsinki and in compliance with the International Council for Harmonization Good Clinical Practice Guidelines. All patients provided written informed consent. The final protocol, any amendments, and informed consent documentations were reviewed and approved by the Institutional Review Boards at each of the investigational centers participating in the study.
Consent for publication
PN declares no conflicts of interest. HSR reports research grant to her institution from Eli Lilly and Company, Pfizer, Merck, Novartis, Genentech, OBI, Odonate, Daiichi-Sankyo, Eisai, Seattle Genetics, Macrogenics, Sermonixs, Immunomedics, AstraZeneca; travel support from Daiichi- Sankyo, Mylan, Pfizer, Merck, Novartis, AstraZeneca, Macrogenics; and honoraria from Puma, Mylan, and Samsung. SMT reports research grants to her institute and personal fees (honoraria for consulting/advisory board) from Eli Lilly and Company, AstraZeneca, Merck, Nektar, Novartis, Pfizer, Genentech/Roche, Exelixis, Bristol-Myers Squibb, Eisai, Nanostring, Sanofi, Odonate, Immunomedics/Gilead; honoraria for advisory board/consulting from Puma, Celldex, Seattle Genetics, Silverback Therapeutics, G1 Therapeutics, Abbvie, Athenex, OncoPep, Kyowa Kirin Pharmaceuticals, Daiichi-Sankyo, CytomX, Samsung Bioepsis Inc., Certara, Mersana Therapeutics, OncoSec; and research funding from Cyclacel. HI reports honoraria and consulting fees from Chugai, Novartis, AstraZeneca, Pfizer, Eli Lilly and Company, Daichi-Sankyo, Eisai, Kyowa Hakko Kirin; grants from MSD, Bayer, Nihon Kayaku, Boehringer Ingelheim, Sanofi; and personal fees from Taiho. MT reports research grant and honoraria from Chugai, Takeda, Pfizer, Kyowa-Kirin, Taiho, Eisai, AstraZeneca, Daiichi-Sankyo, Shimadzu, Yakult, and Nippon Kayaku; research grant from JBCRG association, Astellas, AFI technologies, Shionogi, and GL Science; advisory role at Kyowa-Kirin, Daiichi-Sankyo, Eli Lilly and Company, Konica Minolta, Athenex Oncology, Bertis, Terumo, Luxonus, and Kansai Medical Net; honoraria from BMS, Eli Lilly and Company, MSD, Exact Science, Novartis, and Konica Minolta. He is also on the Board of Directors for DBCRG association, Organization for Oncology and Translational Research, Kyoto Breast Cancer Research Network. MPG reports consulting fees to his institution from Eagle pharmaceuticals, Biovica, Novartis, Context Therapeutics, Biotheranostics, and AstraZeneca; research grants and consulting fees to his institution from Eli Lilly and Company, Pfizer, and Sermonix. PAK reports grants from Eli Lilly and Company. YL, NH, and KCH are employees of Eli Lilly and Company. GWS reports grants and nonfinancial support from Stanford University during the conduct of the study; personal fees from Radius Pharmaceuticals and Verseau Therapeutics, grants from Pfizer, personal fees from Symphogen, personal fees and nonfinancial support from Tessa, and personal fees from Syndax outside the submitted work.
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Neven, P., Rugo, H.S., Tolaney, S.M. et al. Abemaciclib plus fulvestrant in hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in premenopausal women: subgroup analysis from the MONARCH 2 trial. Breast Cancer Res 23, 87 (2021). https://0-doi-org.brum.beds.ac.uk/10.1186/s13058-021-01463-2
- Advanced breast cancer
- CDK4 and 6 inhibitor
- Premenopausal women