Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women

Table 3 Odds ratios of breast cancer risk in relation to p-mTOR expression associated with body size measurements by tumor ER status

Body size measurement		ER+ tumors			ER– tumors
	p-mTOR overexpressed cases vs controls	p-mTOR negative/low cases vs controls	P-heterogeneity	p-mTOR overexpressed cases vs controls	p-mTOR negative/low cases vs controls	P-heterogeneity
	OR (95% CI)	OR (95% CI)		OR (95% CI)	OR (95% CI)
BMI, kg/m²
No. of cases/no. of controls	164/1973	309/1973		25/1973	211/1973
< 25	1.00 [reference]	1.00 [reference]		1.00 [reference]	1.00 [reference]
25–29.99	1.29 (0.77–2.16)	1.02 (0.72–1.45)		0.83 (0.23–2.99)	1.00 (0.68–1.49)
30–34.99	1.48 (0.87–2.52)	1.33 (0.92–1.91)		1.72 (0.54–5.48)	0.84 (0.54–1.31)
≥ 35	1.39 (0.82–2.34)	0.75 (0.51–1.11)	0.015	0.90 (0.25–3.25)	0.61 (0.39–0.96)	0.09
P-trend	0.27	0.18		0.97	0.015
WC
No. of cases/no. of controls	162/1955	304/1955		25/1955	206/1955
Q1	1.00 [reference]	1.00 [reference]		1.00 [reference]	1.00 [reference]
Q2	1.65 (0.90–3.01)	1.09 (0.74–1.60)		1.81 (0.32–10.1)	1.09 (0.70–1.70)
Q3	2.28 (1.28–4.06)	1.36 (0.93–1.98)		4.70 (1.00–22.07)	1.04 (0.57–1.63)
Q4	1.93 (1.06–3.51)	1.01 (0.67–1.50)	0.26	2.60 (0.50–13.6)	0.83 (0.52–1.32)	0.55
P-trend	0.050	0.97		0.25	0.31
WHR
No. of cases/no. of controls	162/1955	304/1955		25/1955	206/1955
Q1	1.00 [reference]	1.00 [reference]		1.00 [reference]	1.00 [reference]
Q2	1.17 (0.57–2.04)	1.34 (0.91–1.98)		1.58 (0.26–9.59)	1.34 (0.85–2.10)
Q3	1.54 (0.91–2.60)	1.47 (1.00–2.15)		5.35 (1.16–24.71)	1.28 (0.80–2.03)
Q4	1.69 (1.01–2.84)	1.37 (0.93–2.03)	0.36	3.42 (0.68–17.16)	1.60 (0.99–2.58)	0.89
P-trend	0.027	0.14		0.08	0.38

Abbreviations: BMI body mass index, ER estrogen receptor, OR odds ratio, Q quartile, WC waist circumference, WHR waist-to-hip ratio
Models adjusted for age, race, family history of breast cancer, menopausal status, age of menarche, parity, history of breastfeeding, oral contraceptive use, and history of diabetes

ISSN: 1465-542X