Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women

Table 2 Odds ratios of breast cancer risk in relation to p-mTOR expression associated with body size measurements

Body size measurement	p-mTOR overexpressed cases vs controls	p-mTOR negative/low cases vs controls	P-heterogeneity
Body size measurement	OR (95% CI)	OR (95% CI)	P-heterogeneity
BMI, kg/m²
No. of cases/no. of controls	189/1973	522/1973
< 25	1.00 [reference]	1.00 [reference]
25–29.99	1.22 (0.75–1.97)	1.02 (0.77–1.35)
30–34.99	1.52 (0.92–2.47)	1.11 (0.83–4.19)
≥ 35	1.31 (0.80–2.13)	0.70 (0.52–0.95)	0.011
P-trend	0.31	0.017
WC
No. of cases/no. of controls	187/1955	512/1955
Q1	1.00 [reference]	1.00 [reference]
Q2	1.67 (0.74–2.96)	1.10 (0.81–1.50)
Q3	2.52 (1.46–4.34)	1.24 (0.91–1.67)
Q4	1.99 (1.12–3.50)	0.94 (0.69–1.30)	0.27
P-trend	0.029	0.64
WHR
No. of cases/no. of controls	187/1955	512/1955
Q1	1.00 [reference]	1.00 [reference]
Q2	1.21 (0.71–2.06)	1.30 (0.96–1.77)
Q3	1.82 (1.11–2.98)	1.32 (0.97–1.80)
Q4	1.81 (1.11–2.98)	1.34 (0.98–1.83)	0.48
P-trend	0.009	0.10

Abbreviations: BMI body mass index, OR odds ratio, Q quartile, WC waist circumference, WHR waist-to-hip ratio
Models adjusted for age, race, family history of breast cancer, menopausal status, age of menarche, parity, history of breastfeeding, oral contraceptive use, and history of diabetes
Waist circumference (WC) quartile cutoffs: 83.7, 94.7, and 107.4 inches
Waist-to-hip ratio (WHR) quartile cutoffs: 0.804, 0.855, and 0.911
P-heterogeneity: tests for differences in the associations of body fatness measurements between p-mTOR overexpressed tumors and p-mTOR negative/low tumors

ISSN: 1465-542X