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Table 1 Selected characteristics of demographics, body fatness, and breast tumors of the cases and controls

From: Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women

Characteristic

Cases with p-mTOR overexpressed tumors (n = 192)a

Cases with p-mTOR negative/low tumors (n = 523)

Controls (n = 1983)

P value (p-mTOR overexpressed vs controls)b

P value (p-mTOR negative/low vs controls)b

P value (p-mTOR overexpressed vs p-mTOR negative/low)b

Age, mean (SD), years

53.8 (10.7)

52.5 (11.1)

48.6 (9.4)

< 0.001

< 0.001

0.16

Race, no. (%)

      

 Black

159 (82.8)

415 (79.4 )

1270 (64.0)

< 0.001

< 0.001

0.30

 White

33 (17.2)

108 (20.6)

713 (36.0)

   

Menopausal status, no. (%)

      

 Premenopausal

86 (44.8)

241 (46.1)

982 (49.5)

0.21

0.16

0.76

 Postmenopausal

106 (55.2)

282 (53.9)

1001 (50.5)

   

BMI, kg/m2, no. (%)

      

  < 25.0

31 (16.2)

121 (23.1)

553 (27.9)

0.001

0.010

0.033

 25.0–29.9

49 (25.5)

150 (28.7)

534 (26.9)

   

 30.0–34.9

51 (26.6)

135 (25.8)

400 (20.2)

   

  ≥ 35.0

61 (31.8)

117 (22.4)

496 (25.0)

   

WC, inches, no.

190

513

1965

   

 Mean (SD)

102.8 (17.9)

98.2 (14.7)

96.7 (17.1)

< 0.001

0.07

0.002

WHR, no.

190

513

1965

   

 Mean (SD)

0.88 (0.08)

0.88 (0.09)

0.86 (0.09)

< 0.001

< 0.001

0.29

Percentage body fat, no.

182

496

1893

   

 Mean (SD), %

41.1 (7.6)

39.2 (7.6)

38.8 (8.8)

< 0.001

0.22

0.006

Fat mass index, no.

181

495

1868

   

 Mean (SD), kg/m2

13.8 (5.1)

12.3 (4.7)

12.3 (5.7)

< 0.001

0.78

< 0.001

ER status, no. (%)

      

 Positive

167 (87.0)

310 (59.5)

–

–

–

< 0.001

 Negative

25 (13.0)

211 (40.5)

–

–

–

 

PR status, no. (%)

      

 Positive

163 (85.8)

308 (59.2)

–

–

–

< 0.001

 Negative

27 (14.2)

213 (40.9)

–

–

–

 

HER2 status, no. (%)

      

 Positive

31 (17.2)

111 (22.0)

–

–

–

0.18

 Negative

149 (82.8)

394 (78.0)

–

–

–

 
  1. Abbreviations: BMI body mass index, ER estrogen receptor, HER2 human epidermal growth factor receptor 2, PR progesterone receptor, SD standard deviation, WC waist circumference, WHR waist-to-hip ratio
  2. ap-mTOR overexpression defined as H-score ≥ 80 (the 75th percentile); p-mTOR negative/low expression defined as H-score < 80
  3. bEstimated by t test for continuous variables and chi-square test for categorical variables