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Table 7 Combined effect of chest X-ray exposure and genetic variants

From: Diagnostic chest X-rays and breast cancer risk among women with a hereditary predisposition to breast cancer unexplained by a BRCA1 or BRCA2 mutation

Chest X-ray exposure & number of DNA repair rare variants

Number of

  

Multiple imputation

Cases

Ctrls

ORa

95%CI

ORa

95%CI

Group ‘Low’b

 Ever & 0 variant

604

580

1

 

1

 

 Ever & 1 variant

197

288

0.67

0.52-0.86

0.67

0.52-0.87

 Ever & 2 variants

34

69

0.52

0.32-0.84

0.49

0.30-0.79

 Ever & ≥3 variants

3

14

0.25

0.06-1.00

0.25

0.06-0.99

 Never

135

195

0.50

0.37-0.68

0.31

0.18-0.52

 Continuouse

  

0.69

0.57-0.84

0.69

0.58-0.83

 Never & 0 variant

101

128

1

 

1

 

 Never & 1 variant

27

50

0.56

0.30-1.06

0.56

0.30-1.05

 Never & 2 variants

7

16

0.52

0.17-1.57

0.48

0.16-1.44

 Never & ≥3 variants

0

1

-

 

-

 

 Ever & 0 variant

604

580

1.67

1.19-2.34

1.66

1.18-2.34

 Ever & 1 variant

197

288

1.12

0.77-1.62

1.12

0.77-1.64

 Ever & 2 variants

34

69

0.86

0.50-1.51

0.82

0.46-1.43

 Ever &≥3 variants

3

14

0.42

0.10-1.71

0.42

0.10-1.71

Group ‘No Effect’c

 Ever & 0 variant

484

535

1

 

1

 

 Ever & 1 variant

258

318

0.96

0.76-1.22

0.97

0.76-1.23

 Ever & 2 variants

81

78

1.12

0.76-1.65

1.15

0.77-1.70

 Ever & ≥3 variants

15

20

1.21

0.55-2.70

1.28

0.57-2.87

 Never

135

195

0.58

0.43-0.78

0.61

0.40-0.94

 Continuouse

  

1.02

0.86-1.21

1.05

0.90-1.21

 Never & 0 variant

74

114

1

 

1

 

 Never & 1 variant

45

67

1.08

0.62-1.90

1.08

0.61-1.89

 Never & 2 variants

14

12

1.40

0.55-3.59

1.50

0.59-3.84

 Never & ≥3 variants

2

2

1.90

0.23-15.8

1.93

0.23-16.1

 Ever & 0 variant

484

535

1.85

1.27-2.70

1.85

1.27-2.71

 Ever & 1 variant

258

318

1.77

1.19-2.65

1.78

1.19-2.66

 Ever & 2 variants

81

78

2.07

1.25-3.42

2.13

1.29-3.54

 Ever & ≥3 variants

15

20

2.24

0.95-5.32

2.39

1.01-5.64

Group ‘High’d

 Ever & 0 variant

343

551

1

 

1

 

 Ever & 1 variant

327

291

2.06

1.62-2.63

2.07

1.62-2.65

 Ever & 2 variants

122

93

2.34

1.66-3.31

2.28

1.60-3.23

 Ever & ≥3 variants

46

16

4.61

2.34-9.08

4.65

2.35-9.22

 Never

135

195

0.85

0.63-1.16

0.74

0.49-1.13

 Continuouse

  

1.67

1.42-1.96

1.66

1.44-1.90

 Never & 0 variant

70

104

1

 

1

 

 Never & 1 variant

46

62

0.90

0.51-1.58

0.88

0.50-1.54

 Never & 2 variants

13

23

0.66

0.27-1.57

0.58

0.24-1.41

 Never & ≥3 variants

6

6

2.01

0.54-7.48

2.01

0.54-7.45

 Ever & 0 variant

343

551

1.12

0.75-1.65

1.10

0.75-1.63

 Ever & 1 variant

327

291

2.30

1.54-3.44

2.28

1.53-3.40

 Ever & 2 variants

122

93

2.61

1.63-4.19

2.51

1.56-4.03

 Ever & ≥3 variants

46

16

5.15

2.43-10.9

5.10

2.41-10.8

  1. Abbreviations: OR (95%CI) odds ratio (95% confidence interval)
  2. aAdjusted for age at censoring, birth cohort (≤1945; 1946-1959; ≥1960), number of full-term pregnancies (>2; 1-2; 0), mammography use (never; ever), educational level (intermediate/high; basic; not graduated), BMI (18.5-24.99; <18.5; ≥25 and <30; ≥30), smoking (no; current; past), and two other DNA repair genes groups
  3. bat least one variant in a gene from Group ‘Low’
  4. cat least one variant in a gene from Group ‘No Effect’
  5. dat least one variant in a gene from Group ‘High’
  6. e“Never” excluded
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Breast Cancer Research

ISSN: 1465-542X

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