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Fig. 3 | Breast Cancer Research

Fig. 3

From: Transcriptome and genome evolution during HER2-amplified breast neoplasia

Fig. 3

Trans-activating effect of HER2 amplification in DCIS from HER2-positive patients. a Principal component analysis on gene expression of DCISs for each patient. The samples were colored by their HER2 amplification status as measured by HER2-FISH. The larger symbols for each group denote the center of each cluster in PCA plot. b Heatmap of the mean-centered expressions of the 43 interferon-stimulated genes (ISGs) between DCIS_amp and DCIS_noamp. These 43 ISGs were identified by gene set enrichment analysis (GSEA) on the upregulated genes in comparison between DCIS_amp and DCIS_noamp. Patient IDs and sample types were denoted as the top bar. c Boxplot of ISG-signature scores between DCIS_amp and DCIS_noamp for each patient. The ISG scores are derived from the gene expressions of 43 ISGs

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