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Fig. 6 | Breast Cancer Research

Fig. 6

From: High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

Fig. 6

Higher cancer cell IRF8 expression levels is associated with an increased infiltration of CD8+ T cells. a Lymphoid cell percentages were quantified as a percentage of total CD45+ cells in ER-negative BC samples classified according to IRF8 cancer cell expression as in Fig. 1. b Representative images of CD8 staining in ER-negative BC by using quantitative multiplex immunohistochemistry (AEC chromogenic staining). c Percentage of CD8+GrzmB+ cells in the total CD8+ T cell population infiltrating tumors. d Percentage of Ki67+ in CD8+GrzmB+ T cell population. e Correlation between IRF8 protein expression and molecules associated with the antitumor immune response. *p < 0.05

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