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Fig. 1 | Breast Cancer Research

Fig. 1

From: High IRF8 expression correlates with CD8 T cell infiltration and is a predictive biomarker of therapy response in ER-negative breast cancer

Fig. 1

Immunohistochemical staining of IRF8 expression in BC and sentinel nodes samples. a Grade 1 breast tumors (G1, n = 11), grade 2 breast tumors (G2, n = 52), grade 3 breast tumors (G3, n = 21), and lymph node metastases (LN, n = 13) (left panel). Negative (secondary antibody alone) and positive controls (tonsils) are shown (right panel). Anti-IRF8 immunoreactivity is shown as the brown-stained cells, whereas cells that are unreactive to the anti-IRF8 antibody are indicated by the blue (hematoxylin) counterstain. Magnification, × 400. b Representative pictures of the different staining patterns for the entire score range from 0 to 3 (upper panel). Stratification of tumors according to staining intensity (score) for IRF8 (0: negative, + 1: weak, + 2: moderate, + 3: strong) (lower panel). c Stratification of the tumors as low or high IRF8 expression according to score classification (low: < 2 score, high: ≥ 2). p value as determined by Fisher’s exact test

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