From: Clonality of circulating tumor cells in breast cancer brain metastasis patients
 | ≥ 5 CTCs (EpCAM dependent) | ≥ 1 CTC (EpCAM independent) | ||||||
---|---|---|---|---|---|---|---|---|
Total (n) | Neg (n) | Pos (n) | p value | Total (n) | Neg (n) | Pos (n) | p value | |
Total | 44 | 35 | 9 | Â | 46 | 31 | 15 | Â |
Histology | ||||||||
 Ductal | 24 | 20 | 4 | 0.655 | 25 | 17 | 8 | 0.552 |
 Lobular | 4 | 3 | 1 |  | 5 | 3 | 2 |  |
 Others | 2 | 1 | 1 |  | 3 | 1 | 2 |  |
 n.a. | 14 |  |  |  | 13 |  |  |  |
Age at BM | ||||||||
 < Mean | 21 | 15 | 6 | 0.213 | 25 | 18 | 7 | 0.476 |
 > Mean | 23 | 20 | 3 |  | 21 | 13 | 8 |  |
Hormone | ||||||||
 Neg | 21 | 17 | 4 | 0.878 | 20 | 9 | 11 | 0.018 |
 Receptor |  |  |  |  |  |  |  |  |
 Pos | 19 | 15 | 4 |  | 21 | 17 | 4 |  |
 n.a. | 4 |  |  |  | 5 |  |  |  |
ERBB2 | ||||||||
 Neg | 16 | 10 | 6 | 0.029 | 15 | 6 | 9 | 0.021 |
 Pos | 24 | 22 | 2 |  | 26 | 20 | 6 |  |
 n.a. | 4 |  |  |  | 5 |  |  |  |
Subtype | ||||||||
 HR-pos | 8 | 5 | 3 | 0.102 | 5 | 3 | 2 | 0.044 |
 TNBC | 8 | 5 | 3 |  | 10 | 3 | 7 |  |
 ERBB2-pos | 24 | 22 | 2 |  | 26 | 20 | 6 |  |
 n.a. | 4 |  |  |  | 5 |  |  |  |
Brain surgery | ||||||||
 No OP | 14 | 10 | 4 | 0.388 | 15 | 9 | 6 | 0.471 |
 OP | 30 | 25 | 5 |  | 20 | 22 | 9 |  |
 n.a. | 0 |  |  |  | 11 |  |  |  |
Oligo brain met. | ||||||||
 Multiple | 30 | 24 | 6 | 0.827 | 28 | 16 | 12 | 0.080 |
 Oligo | 13 | 10 | 3 |  | 17 | 14 | 3 |  |
 n.a. | 1 |  |  |  | 1 |  |  |  |
Bone met. | ||||||||
 No | 25 | 23 | 2 | 0.021 | 25 | 18 | 7 | 0.476 |
 Yes | 19 | 12 | 7 |  | 21 | 13 | 8 |  |
Liver met. | ||||||||
 No | 33 | 28 | 5 | 0.165 | 31 | 22 | 9 | 0.471 |
 Yes | 11 | 7 | 4 |  | 15 | 9 | 6 |  |
Pulmonary met. | ||||||||
 No | 36 | 29 | 7 | 0.743 | 38 | 28 | 10 | 0.064 |
 Yes | 8 | 6 | 2 |  | 8 | 3 | 5 |  |