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Fig. 9 | Breast Cancer Research

Fig. 9

From: Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

Fig. 9

Prophylactic vaccination with 4T1.G-CSF− cells. a Balb/cByJ mice received 5 × 105 irradiated EMT6 cells or 5 × 105 irradiated EMT6 cells and 1 × 106 irradiated 4T1 cells on opposite sides (contralateral 4T1 vaccine) or 5 × 105 irradiated EMT6 cells and 1 × 106 irradiated 4T1.G-CSF− cells on opposite sides (contralateral 4T1.G-CSF− vaccine) twice, 10 days apart. Ten days after the booster vaccination, all mice were challenged with 5 × 105 live EMT6 cells. Additionally, naive mice that received only 5 × 105 live EMT6 cells served as controls. Tumor-free survival was recorded. b Balb/cByJ mice were vaccinated with 1 × 106 4T1 cells or 1 × 106 4T1.G-CSF− cells, twice 10 days apart. Ten days after the booster vaccination, mice were challenged with live 5 × 105 4T1 cells or 5 × 105 4T1.G-CSF− cells, respectively. Naive mice that received only 5 × 105 live 4T1 cells, served as controls. Tumor-free survival was recorded (**p < 0.01, log-rank analysis)

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