Clonal relatedness in tumour pairs of breast cancer patients

Biermann, Jana; Parris, Toshima Z.; Nemes, Szilárd; Danielsson, Anna; Engqvist, Hanna; Werner Rönnerman, Elisabeth; Forssell-Aronsson, Eva; Kovács, Anikó; Karlsson, Per; Helou, Khalil

doi:10.1186/s13058-018-1022-y

Table 1 Overview of the clinical and histological characteristics of the primary and secondary tumours

					Primary tumour				Secondary tumour
Patient	Laterality	Synchronicity	Group	Time interval (days)	Histology	ER	HER2	Molecular subtype	Histology	ER	HER2	Molecular subtype	Discordance	Clinical classification
BM1	bilateral	metachronous	BM	346	Invasive carcinoma NST	pos	neg	ND	ND	pos	neg	ND		concordant
BM2	bilateral	metachronous	BM	1694	Invasive carcinoma NST	pos	neg	Luminal B	Invasive lobular carcinoma	pos	neg	ND	Histology	discordant
BM3	bilateral	metachronous	BM	1652	ND	pos	neg	ND	Invasive carcinoma NST	pos	neg	ND		concordant
BM4	bilateral	metachronous	BM	581	Invasive carcinoma NST	neg	neg	Basal-like	Invasive carcinoma NST	neg	neg	ND		concordant
BM5	bilateral	metachronous	BM	1954	Invasive carcinoma NST	pos	neg	ND	Invasive lobular carcinoma	pos	neg	ND	Histology	discordant
BM6	bilateral	metachronous	BM	1417	Invasive lobular carcinoma	pos	neg	ND	Invasive carcinoma NST	neg	neg	HER2/ER-	Histology; ER	discordant
BM7	bilateral	metachronous	BM	456	Invasive carcinoma NST	pos	pos	ND	Invasive carcinoma NST	neg	pos	ND	ER	discordant
BM8	bilateral	metachronous	BM	1152	Invasive lobular carcinoma	pos	neg	ND	Invasive lobular carcinoma	pos	neg	ND		concordant
BM9	bilateral	metachronous	BM	972	Invasive carcinoma NST	neg	neg	ND	Invasive carcinoma NST	neg	neg	ND		concordant
BS1	bilateral	synchronous	BS	0	Invasive carcinoma NST	pos	neg	ND	Invasive carcinoma NST	pos	neg	Luminal B		concordant
BS2	bilateral	synchronous	BS	0	Invasive lobular carcinoma	pos	neg	ND	Invasive carcinoma NST	pos	neg	Luminal B	Histology	discordant
BS3	bilateral	synchronous	BS	14	Invasive carcinoma NST	pos	neg	ND	Invasive carcinoma NST	pos	neg	ND		concordant
BS4	bilateral	synchronous	BS	0	ND	pos	neg	ND	ND	pos	neg	ND		concordant
BS5	bilateral	synchronous	BS	6	Invasive carcinoma NST	pos	neg	ND	Invasive carcinoma NST	ND	neg	ND		concordant
BS6	bilateral	synchronous	BS	0	ND	neg	neg	ND	ND	neg	neg	ND		concordant
BS7	bilateral	synchronous	BS	0	Invasive carcinoma NOS	pos	neg	Luminal B	Invasive lobular carcinoma	neg	neg	ND	Histology; ER	discordant
BS8	bilateral	synchronous	BS	0	Invasive carcinoma NST	pos	neg	ND	Invasive carcinoma NST	pos	neg	ND		concordant
IM1	ipsilateral	metachronous	IM	1855	ND	pos	neg	ND	ND	pos	neg	Luminal B		concordant
IM2	ipsilateral	metachronous	IM	448	ND	neg	neg	ND	ND	neg	neg	ND		concordant
IM3	ipsilateral	metachronous	IM	1944	Invasive carcinoma NST	pos	pos	Luminal B	ND	pos	pos	Luminal B		concordant
IM4	ipsilateral	metachronous	IM	567	Invasive carcinoma NST	pos	neg	Luminal B	ND	pos	neg	HER2/ER-	Subtype	discordant
IM5	ipsilateral	metachronous	IM	712	Invasive carcinoma NST	neg	neg	Basal-like	ND	neg	neg	ND		concordant
IM6	ipsilateral	metachronous	IM	664	ND	pos	neg	ND	ND	pos	neg	ND		concordant
IM7	ipsilateral	metachronous	IM	2454	ND	pos	neg	ND	ND	pos	neg	ND		concordant
IM8	ipsilateral	metachronous	IM	563	Invasive carcinoma NST	pos	neg	ND	Invasive lobular carcinoma	pos	neg	Luminal B	Histology	discordant
IM9	ipsilateral	metachronous	IM	2142	Invasive carcinoma NOS	ND	neg	Luminal B	Invasive carcinoma NOS	pos	neg	Luminal B		concordant
IS1	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	neg	neg	Basal-like	Invasive carcinoma NST	neg	pos	Luminal B	HER2; subtype	discordant
IS2	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	pos	neg	ND	ND	pos	neg	Luminal B		concordant
IS3	ipsilateral	synchronous	IS	0	ND	neg	neg	Basal-like	ND	neg	pos	Basal-like	HER2	discordant
IS4	ipsilateral	synchronous	IS	50	ND	neg	neg	ND	ND	pos	neg	Luminal B	ER	discordant
IS5	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	pos	neg	Luminal B	Invasive carcinoma NST	pos	neg	Luminal B		concordant
IS6	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	pos	neg	ND	ND	pos	neg	ND		concordant
IS7	ipsilateral	synchronous	IS	0	Invasive carcinoma NOS	pos	neg	ND	ND	pos	neg	ND		concordant
IS8	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	pos	neg	Luminal B	ND	pos	neg	ND		concordant
IS9	ipsilateral	synchronous	IS	0	ND	neg	pos	Basal-like	ND	neg	neg	ND	HER2	discordant
IS10	ipsilateral	synchronous	IS	0	Invasive carcinoma NST	pos	neg	Luminal B	ND	pos	neg	Luminal B		concordant
IS11	ipsilateral	synchronous	IS	0	Invasive carcinoma NOS	neg	pos	HER2/ER-	ND	neg	pos	HER2/ER-		concordant

ER oestrogen receptor status, HER2 human epidermal growth factor receptor 2 status, ND not determined, NOS not otherwise specified, NST no special type

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ISSN: 1465-542X

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