Fig. 8

Basal and ADP-stimulated MFI of platelet antigenes in orthotopic murine 4T1 breast cancer model. Median expression of P-selectin (a), active form of GPIIb/IIIa (b), bound von Willebrand factor (vWF) (c), and fibrinogen (d) shown as median fluorescence intensity (MFI). Data presented as median and IQR. Black circle indicates outlier. Data analyzed with Kruskal–Wallis test followed by Dunn’s multiple comparison test since they either did not display normal distribution and/or their variances were heterogeneous. a n = 10, n = 7, n = 9, n = 7, n = 8, and n = 12 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week, respectively; and n = 9, n = 7, n = 8, n = 6, n = 6, and n = 12 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week after ADP stimulation. b n = 10, n = 7, n = 9, n = 7, n = 8, and n = 13 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week, respectively; and n = 10, n = 7, n = 9, n = 7, n = 7, and n = 13 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week after ADP stimulation. c n = 10, n = 7, n = 8, n = 7, n = 8, and n = 18 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week, respectively; and n = 10, n = 7, n = 9, n = 7, n = 7, and n = 19 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week after ADP stimulation. d n = 10, n = 7, n = 8, n = 7, n = 8, and n = 20 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week, respectively; and n = 9, n = 7, n = 9, n = 7, n = 8, and n = 20 for healthy control, 1st, 2nd, 3rd, 4th, and 5th week after ADP stimulation. Statistical significance at level of **P < 0.01 and ***P < 0.001. AU arbitrary units